Journal article
Multivariate GWAS of Structural Dental Anomalies and Dental Caries in a Multi-Ethnic Cohort
Frontiers in dental medicine, Vol.2, 771116
2022
DOI: 10.3389/fdmed.2021.771116
PMCID: PMC9581442
PMID: 36267138
Abstract
Odontogenesis is a complex process, where disruption can result in dental anomalies and/or increase the risk of developing dental caries. Based on previous studies, certain dental anomalies tend to co-occur in patients, suggesting that these traits may share common genetic and etiological components. The main goal of this study was to implement a multivariate genome-wide association study approach to identify genetic variants shared between correlated structural dental anomalies and dental caries. Our cohort (
N
= 3,579) was derived from the Pittsburgh Orofacial Clefts Study, where multiple dental traits were assessed in both the unaffected relatives of orofacial cleft (OFC) cases (
n
= 2,187) and unaffected controls (
n
= 1,392). We identified four multivariate patterns of correlated traits in this data: tooth agenesis, impaction, and rotation (AIR); enamel hypoplasia, displacement, and rotation (HDR); displacement, rotation, and mamelon (DRM); and dental caries, tooth agenesis and enamel hypoplasia (CAH). We analyzed each of these four models using genome-wide multivariate tests of association. No genome-wide statistically significant results were found, but we identified multiple suggestive association signals (
P
< 10
−5
) near genes with known biological roles during tooth development, including
ADAMTS9
and
PRICKLE2
associated with AIR;
GLIS3
,
WDR72
, and
ROR2
associated with HDR and DRM;
ROBO2
associated with DRM;
BMP7
associated with HDR; and
ROBO1, SMAD2
, and
MSX2
associated with CAH. This is the first study to investigate genetic associations for multivariate patterns of correlated dental anomalies and dental caries. Further studies are needed to replicate these results in independent cohorts.
Details
- Title: Subtitle
- Multivariate GWAS of Structural Dental Anomalies and Dental Caries in a Multi-Ethnic Cohort
- Creators
- Rasha N. Alotaibi - King Saud UniversityBrian J. Howe - University of IowaLina M. Moreno Uribe - University of IowaConsuelo Valencia RamirezClaudia RestrepoFrederic W.B. Deleyiannis - University of Colorado HealthCarmencita Padilla - University of the Philippines ManilaIeda M. Orioli - Universidade Federal do Rio de JaneiroCarmen J. Buxó - University of Puerto Rico SystemJacqueline T. Hecht - The University of Texas Health Science Center at HoustonGeorge L. Wehby - University of IowaKatherine Neiswanger - University of PittsburghJeffery C. Murray - University of IowaJohn R. Shaffer - University of PittsburghSeth M. Weinberg - University of PittsburghMary L. Marazita - University of Pittsburgh
- Resource Type
- Journal article
- Publication Details
- Frontiers in dental medicine, Vol.2, 771116
- DOI
- 10.3389/fdmed.2021.771116
- PMID
- 36267138
- PMCID
- PMC9581442
- NLM abbreviation
- Front Dent Med
- ISSN
- 2673-4915
- eISSN
- 2673-4915
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health
- Language
- English
- Date published
- 2022
- Academic Unit
- Preventive and Community Dentistry; Health Management and Policy; Dental Clinic Administration; Pediatric Dentistry; Craniofacial Anomalies Research Center; Family Dentistry; Orthodontics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Economics; Public Policy Center (Archive); Dental Research
- Record Identifier
- 9984367695802771
Metrics
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