Journal article
Municipal drinking water nitrate level and cancer risk in older women: the Iowa Women's Health Study
Epidemiology (Cambridge, Mass.), Vol.12(3), pp.327-338
05/2001
DOI: 10.1097/00001648-200105000-00013
PMID: 11338313
Abstract
Nitrate contamination of drinking water may increase cancer risk, because nitrate is endogenously reduced to nitrite and subsequent nitrosation reactions give rise to N-nitroso compounds; these compounds are highly carcinogenic and can act systemically. We analyzed cancer incidence in a cohort of 21,977 Iowa women who were 55-69 years of age at baseline in 1986 and had used the same water supply more than 10 years (87% > 20 years); 16,541 of these women were on a municipal supply, and the remainder used a private well. We assessed nitrate exposure from 1955 through 1988 using public databases for municipal water supplies in Iowa (quartile cutpoints: 0.36, 1.01, and 2.46 mg per liter nitrate-nitrogen). As no individual water consumption data were available, we assigned each woman an average level of exposure calculated on a community basis; no nitrate data were available for women using private wells. Cancer incidence (N = 3,150 cases) from 1986 through 1998 was determined by linkage to the Iowa Cancer Registry. For all cancers, there was no association with increasing nitrate in drinking water, nor were there clear and consistent associations for non-Hodgkin lymphoma; leukemia; melanoma; or cancers of the colon, breast, lung, pancreas, or kidney. There were positive associations for bladder cancer [relative risks (RRs) across nitrate quartiles = 1, 1.69, 1.10, and 2.83] and ovarian cancer (RR = 1, 1.52, 1.81, and 1.84), and inverse associations for uterine cancer (RR = 1, 0.86, 0.86, and 0.55) and rectal cancer (RR = 1, 0.72, 0.95, and 0.47) after adjustment for a variety of cancer risk/protective factors, agents that affect nitrosation (smoking, vitamin C, and vitamin E intake), dietary nitrate, and water source. Similar results were obtained when analyses were restricted to nitrate level in drinking water from 1955 through 1964. The positive association for bladder cancer is consistent with some previous data; the associations for ovarian, uterine, and rectal cancer were unexpected.
Details
- Title: Subtitle
- Municipal drinking water nitrate level and cancer risk in older women: the Iowa Women's Health Study
- Creators
- Peter J Weyer - Center for Health Effects of Environmental Contamination, University of Iowa, USAJames R CerhanBurton C KrossGeorge R HallbergJiji KantamneniGeorge BreuerMichael P JonesWei ZhengCharles F Lynch
- Resource Type
- Journal article
- Publication Details
- Epidemiology (Cambridge, Mass.), Vol.12(3), pp.327-338
- DOI
- 10.1097/00001648-200105000-00013
- PMID
- 11338313
- NLM abbreviation
- Epidemiology
- ISSN
- 1044-3983
- eISSN
- 1531-5487
- Publisher
- United States
- Grant note
- R01 CA39741 / NCI NIH HHS P30 ES05605 / NIEHS NIH HHS K07 CA64220 / NCI NIH HHS
- Language
- English
- Date published
- 05/2001
- Academic Unit
- Statistics and Actuarial Science; Occupational and Environmental Health; Epidemiology; Biostatistics; Public Policy Center (Archive)
- Record Identifier
- 9983985918702771
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