Journal article
Murine aortic reactivity is programmed equally by maternal low protein diet or late gestation dexamethasone
The journal of maternal-fetal & neonatal medicine, Vol.20(11), pp.833-841
2007
DOI: 10.1080/14767050701626540
PMID: 17853187
Abstract
Objective. In rats, maternal low protein diet induces growth restriction, increases fetal glucocorticoid exposure and programs cardiovascular and endocrine dysfunction in adult offspring. We hypothesized that both maternal low protein diet and late gestation dexamethasone program murine offspring to develop hypertension, vascular dysfunction, and glucose intolerance.
Methods. An iso-caloric low protein diet (LP) was provided to dams from E0 to E19. Additional dams received a normal protein diet without (NP) or with either dexamethasone (NP-Dex, 0.1 mg kg d sc) or normal saline (NP-NS) from E10 to E18.
Results. Offspring of dams given LP weighed less at 10 days than NP offspring, while Dex administration did not alter pup weight. At 4 months, all four groups had similar systolic blood pressures and no detectable differences were evoked by oral L-NAME. Offspring of LP mice had impaired glucose clearance that was directly correlated with their weight at 10 days. Aortic rings from offspring of both LP and NP-Dex exposed dams had impaired vasodilatation to acetylcholine.
Conclusions. These findings demonstrate that both maternal low protein diet and late gestation dexamethasone program murine offspring to develop endothelial dysfunction in the absence of hypertension, while only maternal LP impaired perinatal growth and glucose clearance in adult offspring.
Details
- Title: Subtitle
- Murine aortic reactivity is programmed equally by maternal low protein diet or late gestation dexamethasone
- Creators
- Robert D Roghair - 1Department of Pediatrics, University of Iowa, Iowa City, IA, USAJeffrey L Segar - 1Department of Pediatrics, University of Iowa, Iowa City, IA, USARobert A Kilpatrick - 1Department of Pediatrics, University of Iowa, Iowa City, IA, USAEmily M Segar - 1Department of Pediatrics, University of Iowa, Iowa City, IA, USAThomas D Scholz - 1Department of Pediatrics, University of Iowa, Iowa City, IA, USAFred S Lamb - 1Department of Pediatrics, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- The journal of maternal-fetal & neonatal medicine, Vol.20(11), pp.833-841
- Publisher
- Informa UK Ltd
- DOI
- 10.1080/14767050701626540
- PMID
- 17853187
- ISSN
- 1476-7058
- eISSN
- 1476-4954
- Language
- English
- Date published
- 2007
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center; Child and Community Health; Neonatology
- Record Identifier
- 9984093229002771
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