Journal article
Muscle Blood Flow and Vasodilation are Blunted at the Onset of Exercise Following an Acute Bout of Ischemia-Reperfusion
Journal of applied physiology (1985), Vol.135(5), pp.1053-1061
11/01/2023
DOI: 10.1152/japplphysiol.00314.2023
PMID: 37767553
Abstract
Ischemia-reperfusion injury (I/R) can inhibit endothelial function and impair nitric oxide bioavailability. We tested the hypothesis that I/R also blunts the rapid and steady-state hyperemic and vasodilatory response to handgrip exercise. Ten subjects (8M/2F; 24±4yr) performed handgrip exercises before and after I/R (20 min of ischemia/20 min of reperfusion) and time control (40 min supine rest) trials. Forearm blood flow (FBF) and vascular conductance (FVC) were assessed with Doppler ultrasound during single forearm contractions and 3 min of rhythmic handgrip exercise. Venous blood samples were drawn at rest and during exercise to assess plasma [nitrite]. Peak ΔFBF (from baseline) and ΔFVC following single contractions were attenuated following I/R (134±48 vs. 103±42 ml·min -1 ; 160±55 vs. 118±48 ml·min -1 ·100 mmHg -1 , P<0.05 for both) but not following time control (115±63 vs. 124±57 ml·min -1 ; 150±80 vs. 148±64 ml·min -1 ·100 mmHg -1 , P=0.16 and P=0.95, respectively). Steady-state ΔFBF and ΔFVC during rhythmic exercise were unchanged in both I/R (192 ± 52 vs. 190±53 ml·min -1 ; 208±56 vs. 193±60 ml·min -1 ·100 mmHg -1 ) and time control (188±54 vs. 196±48 ml·min -1 ; 206±60 vs. 207±49 ml·min -1 ·100 mmHg -1 ) trials (group x time interactions P=0.34 and 0.21, respectively). Plasma [nitrite] under resting conditions and during steady-steady state rhythmic exercise was attenuated following I/R (P<0.05 for both) but not time control (P=0.54 and 0.93). These data indicate I/R blunts hyperemia and vasodilation at the onset of muscle contractions but does not attenuate these responses during steady-state exercise.
Details
- Title: Subtitle
- Muscle Blood Flow and Vasodilation are Blunted at the Onset of Exercise Following an Acute Bout of Ischemia-Reperfusion
- Creators
- Brady E. Hanson - University of IowaAndrew J. Feider - University of IowaSatoshi Hanada - University of IowaAric W. Aldrich - University of IowaDarren P. Casey - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.135(5), pp.1053-1061
- DOI
- 10.1152/japplphysiol.00314.2023
- PMID
- 37767553
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Language
- English
- Electronic publication date
- 09/28/2023
- Date published
- 11/01/2023
- Academic Unit
- Anesthesia; Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984473410002771
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