Muscle Mass Is More Strongly Related to Hip Bone Mineral Density Than Is Quadriceps Strength or Lower Activity Level in Adults Over Age 50 Year

Neil A Segal; James C Torner; Mei Yang; Jeffrey R Curtis; David T Felson; Michael C Nevitt; for the Multicenter Osteoarthritis (MOST) Study Group

doi:10.1016/j.jocd.2008.03.001

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Muscle Mass Is More Strongly Related to Hip Bone Mineral Density Than Is Quadriceps Strength or Lower Activity Level in Adults Over Age 50 Year

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Muscle Mass Is More Strongly Related to Hip Bone Mineral Density Than Is Quadriceps Strength or Lower Activity Level in Adults Over Age 50 Year

Neil A Segal, James C Torner, Mei Yang, Jeffrey R Curtis, David T Felson, Michael C Nevitt and for the Multicenter Osteoarthritis (MOST) Study Group

Journal of clinical densitometry, Vol.11(4), pp.503-510

2008

DOI: 10.1016/j.jocd.2008.03.001

PMID: 18456530

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https://www.ncbi.nlm.nih.gov/pmc/articles/2654209View

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Abstract

This cross-sectional study examined whether reduced hip bone mineral density (BMD) is better explained by isokinetic knee extensor strength (KES), lower limb lean body mass (L-LBM), or Physical Activity Scale for the Elderly (PASE). Through population-based recruitment, 1543 adults without knee osteoarthritis were recruited. For men and women respectively, means ± SD were age 60.8 ± 8.0 and 61.1 ± 7.9 yr; body mass index 29.6 ± 4.6 and 29.1 ± 5.4 kg/m 2; hip BMD 1.025 ± 0.138 and 0.895 ± 0.128 g/cm 2; KES 124.9 ± 41 and 72.7 ± 22.9 N·m; L-LBM 10.3 ± 1.5 and 7.0 ± 1.2 kg; and PASE 206.4 ± 99.7 and 163.8 ± 77.0. The relationship between BMD and KES in men (r 2 = 0.21, p ≥ 0.002) and women (r = 0.23, p < 0.001) was significant before adjustment. However, this association was no longer significant after controlling for L-LBM. Even after controlling for age, race, and sex, the association between BMD and KES was better explained by L-LBM (partial R 2 = 0.14, p < 0.001) than by PASE (partial R 2 = 0.00). Allometric scaling of KES to body size attenuated the association of BMD with KES (Std Beta = 0.03). The significant association between BMD and L-LBM (Std Beta = 0.36) remained stronger than that between BMD and weight (Std Beta = 0.21). Therefore, muscle mass accounted for a greater proportion of the variance in hip BMD than KES or activity level and explained a significant proportion of the association between weight and BMD.

muscle mass

bone mineral density

quadriceps strength

rehabilitation

Allometric scaling

physical activity level

Details

Title: Subtitle: Muscle Mass Is More Strongly Related to Hip Bone Mineral Density Than Is Quadriceps Strength or Lower Activity Level in Adults Over Age 50 Year
Creators: Neil A Segal - University of Iowa and VA Medical Center, Iowa City, IA, USA
James C Torner - University of Iowa and VA Medical Center, Iowa City, IA, USA
Mei Yang - Boston University, Boston, MA, USA
Jeffrey R Curtis - Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA
David T Felson - Boston University, Boston, MA, USA
Michael C Nevitt - University of California San Francisco, San Francisco, CA, USA
for the Multicenter Osteoarthritis (MOST) Study Group
Resource Type: Journal article
Publication Details: Journal of clinical densitometry, Vol.11(4), pp.503-510
DOI: 10.1016/j.jocd.2008.03.001
PMID: 18456530
NLM abbreviation: J Clin Densitom
ISSN: 1094-6950
eISSN: 1559-0747
Publisher: Elsevier Inc
Language: English
Date published: 2008
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983996190502771

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