Journal article
Musculoskeletal Biorepository: Establishment, Sustainment, and Tips for Success
Journal of the American Academy of Orthopaedic Surgeons, Vol.32(11), pp.485-493
04/17/2024
DOI: 10.5435/JAAOS-D-24-00153
PMID: 38652884
Abstract
A biorepository, also referred to as a "biobank," is a collection of biologic samples that are stored for laboratory research. With the emergence of precision medicine, the importance of leveraging individual patient biomolecular signatures to improve diagnosis, prognosis, and treatment is becoming increasingly recognized. Successful development and sustainment of a biorepository provides the potential for transformative preclinical research. Establishing a biobank requires a team approach with involvement of the institutions' research laboratory team and regulatory body. Execution of research activities requires a coordinated team approach for case identification, consent process, data and specimen collection, specimen processing, and storage and archiving. The advancing fields of precision medicine and orthobiologics provide incredible opportunities for institutions to generate novel lines of inquiry in musculoskeletal diseases through a multiomics approach (genomic, transcriptomic, proteomic, microbiomic). In addition, a biobank is an important component of post-market surveillance for the rapidly emerging field of orthobiologics.
Details
- Title: Subtitle
- Musculoskeletal Biorepository: Establishment, Sustainment, and Tips for Success
- Creators
- Joseph W Galvin - University of IowaBrendan M Patterson - University of IowaMaria Bozoghlian - University of IowaJames V Nepola - University of IowaZachary T Colburn - Madigan Army Medical Center
- Resource Type
- Journal article
- Publication Details
- Journal of the American Academy of Orthopaedic Surgeons, Vol.32(11), pp.485-493
- DOI
- 10.5435/JAAOS-D-24-00153
- PMID
- 38652884
- NLM abbreviation
- J Am Acad Orthop Surg
- eISSN
- 1940-5480
- Language
- English
- Electronic publication date
- 04/17/2024
- Academic Unit
- Orthopedics and Rehabilitation
- Record Identifier
- 9984618417402771
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