Journal article
Musculoskeletal Complications of Fluoroquinolones: Guidelines and Precautions for Usage in the Athletic Population
PM & R, Vol.3(2), pp.132-142
2011
DOI: 10.1016/j.pmrj.2010.10.003
PMID: 21333952
Abstract
Fluoroquinolone antibiotics are associated with a wide spectrum of musculoskeletal complications that involve not only tendon but also cartilage, bone, and muscle. Insights into the pathoetiology of fluoroquinolone toxicity on musculoskeletal tissues have been evolving over recent years. Although the pathoetiology is certainly multifactorial, alterations in cell signaling proteins and direct toxic effects on musculoskeletal tissues have been strongly implicated. Increasing age and concomitant systemic corticosteroid use appear to significantly increase the risk of adverse events. The purpose of this article is to review the musculoskeletal complications associated with use of fluoroquinolone antibiotics by adults; identify risk factors associated with fluoroquinolone toxicity; explore the possible pathoetiology of fluoroquinolone toxicity on tendon, cartilage, bone, and muscle; and offer recommendations regarding evaluation and treatment of fluoroquinolone-associated musculoskeletal complications. In addition, this review will provide recommendations regarding fluoroquinolone use in athletes and return to play after fluoroquinolone exposure.
Details
- Title: Subtitle
- Musculoskeletal Complications of Fluoroquinolones: Guidelines and Precautions for Usage in the Athletic Population
- Creators
- Mederic M Hall - Department of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine, Mayo Clinic Sports Medicine Center, Rochester, MN ⁎ ⁎ Disclosure: nothing to discloseJonathan T Finnoff - Mayo Clinic Sports Medicine Center, Mayo Clinic College of Medicine, Rochester, MN † † Disclosure: nothing to discloseJay Smith - Mayo Clinic Sports Medicine Center, Mayo Clinic College of Medicine, 200 1st St SW, Rochester, MN 55905 ‡ ‡ Disclosure: nothing to disclose
- Resource Type
- Journal article
- Publication Details
- PM & R, Vol.3(2), pp.132-142
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.pmrj.2010.10.003
- PMID
- 21333952
- ISSN
- 1934-1482
- eISSN
- 1934-1563
- Language
- English
- Date published
- 2011
- Academic Unit
- Radiology; Orthopedics and Rehabilitation; Family and Community Medicine
- Record Identifier
- 9984024512702771
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