Journal article
Mutant telomeres inhibit transcriptional silencing at native telomeres of the yeast Kluyveromyces lactis
Molecular genetics and genomics : MGG, Vol.268(6), pp.729-738
03/2003
DOI: 10.1007/s00438-002-0788-9
PMID: 12655399
Abstract
We report the identification and characterization of transcriptional silencing at native telomeres in the budding yeast Kluyveromyces lactis. We show that K. lactis telomeres are able to repress the transcription of a gene located at the junction between the telomeric repeat tract and the subtelomeric domain. As in Saccharomyces cerevisiae, switching between the repressed and derepressed transcriptional states occurs. C-terminal truncation of the telomere binding protein Rap1p, which leads to a regulated alteration in telomere length, reduces telomeric silencing. In addition, telomeric silencing is reduced dramatically in telomerase RNA mutants in which telomere length control has been lost. This is consistent with the possibility that the structure of the entire telomere affects the silencing functions exhibited by its internal domain.
Details
- Title: Subtitle
- Mutant telomeres inhibit transcriptional silencing at native telomeres of the yeast Kluyveromyces lactis
- Creators
- R Gurevich - Dept. of Molecular Microbiology and Biotechnology, Tel-Aviv University, IsraelS SmolikovH MaddarA Krauskopf
- Resource Type
- Journal article
- Publication Details
- Molecular genetics and genomics : MGG, Vol.268(6), pp.729-738
- Publisher
- Germany
- DOI
- 10.1007/s00438-002-0788-9
- PMID
- 12655399
- ISSN
- 1617-4615
- eISSN
- 1617-4623
- Language
- English
- Date published
- 03/2003
- Academic Unit
- Biology
- Record Identifier
- 9983991998402771
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