Journal article
Mutations in the yeast PDR3, PDR4, PDR7 and PDR9 pleiotropic (multiple) drug resistance loci affect the transcript level of an ATP binding cassette transporter encoding gene, PDR5
Genetics (Austin), Vol.136(2), pp.505-515
01/01/1994
DOI: 10.1093/genetics/136.2.505
PMCID: PMC1205804
PMID: 8150279
Abstract
The yeast pleiotropic (multiple drug) resistance gene PDR5 encodes a product with homology to a large number of membrane transport proteins including the mammalian multiple drug resistance family. In this study, we identified four genes on chromosome II that affect the steady-state level of PDR5 transcript in addition to a previously identified positive regulator, PDR1. The genes in question are PDR3, PDR4, PDR7 and PDR9. We also analyzed the interaction between PDR5 and YAP1. YAP1 encodes a positive regulator with a leucine zipper motif that causes pleiotropic drug resistance when overproduced. YAP1-mediated pleiotropic drug resistance is not dependent on the presence of PDR5 and must act through other genes.
Details
- Title: Subtitle
- Mutations in the yeast PDR3, PDR4, PDR7 and PDR9 pleiotropic (multiple) drug resistance loci affect the transcript level of an ATP binding cassette transporter encoding gene, PDR5
- Creators
- D Dexter - Department of Biology, Catholic University of America, Washington, D. C. 20064.S Moye-RowleyAi-Ling Wu - Department of Biology, Catholic University of America, Washington, D. C. 20064.J Golin - Department of Biology, Catholic University of America, Washington, D. C. 20064.
- Resource Type
- Journal article
- Publication Details
- Genetics (Austin), Vol.136(2), pp.505-515
- DOI
- 10.1093/genetics/136.2.505
- PMID
- 8150279
- PMCID
- PMC1205804
- NLM abbreviation
- Genetics
- ISSN
- 0016-6731
- eISSN
- 1943-2631
- Language
- English
- Date published
- 01/01/1994
- Academic Unit
- Molecular Physiology and Biophysics; Internal Medicine
- Record Identifier
- 9984297610302771
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