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Mutations in zinc finger 407 [ZNF407] cause a unique autosomal recessive cognitive impairment syndrome
Journal article   Open access   Peer reviewed

Mutations in zinc finger 407 [ZNF407] cause a unique autosomal recessive cognitive impairment syndrome

Marios Kambouris, Rachid C. Maroun, Tawfeg Ben-Omran, Yasser Al-Sarraj, Khaoula Errafii, Rehab Ali, Hala Boulos, Patrick Curmi and Hatem El-Shanti
Orphanet journal of rare diseases, Vol.9(1), pp.80-80
2014
DOI: 10.1186/1750-1172-9-80
PMCID: PMC4070100
PMID: 24907849
url
https://doi.org/10.1186/1750-1172-9-80View
Published (Version of record) Open Access

Abstract

A consanguineous Arab family is affected by an apparently novel autosomal recessive disorder characterized by cognitive impairment, failure-to-thrive, hypotonia and dysmorphic features including bilateral ptosis and epicanthic folds, synophrys, midface hypoplasia, downturned mouth corners, thin upper vermillion border and prominent ears, bilateral 5th finger camptodactyly, bilateral short 4th metatarsal bones, and limited knee mobility bilaterally.
Genetics Life Sciences Biochemistry, Molecular Biology Human genetics

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