Journal article
Mutations of p53 associated with pancreatic cancer and therapeutic implications
Annals of hepato-biliary-pancreatic surgery, Vol.25(3), pp.315-327
08/31/2021
DOI: 10.14701/ahbps.2021.25.3.315
PMCID: PMC8382872
PMID: 34402431
Abstract
Pancreatic adenocarcinoma is a malignancy with rising incidence and grim prognosis. Despite improvements in therapeutics for treating metastatic pancreatic cancer, this disease is invariably fatal with survival time less than a few years. New molecular understanding of the pathogenesis of pancreatic adenocarcinoma based on efforts led by The Cancer Genome Atlas and other groups has elucidated the landscape of this disease and started to produce therapeutic results, leading to the first introduction of targeted therapies for subsets of pancreatic cancers bearing specific molecular lesions such as BRCA mutations. These efforts have highlighted that subsets of pancreatic cancers are particularly sensitive to chemotherapy. The most common molecular lesions in pancreatic adenocarcinomas are mutations in an oncogene
KRAS
and the
TP53
gene that encodes for tumor suppressor protein p53. This paper will review the landscape of pancreatic cancers, focusing on mutations of p53, a major tumor suppressor protein, in pancreatic cancers and possible therapeutic repercussions.
Details
- Title: Subtitle
- Mutations of p53 associated with pancreatic cancer and therapeutic implications
- Creators
- Ioannis A. Voutsadakis - NOSM University
- Resource Type
- Journal article
- Publication Details
- Annals of hepato-biliary-pancreatic surgery, Vol.25(3), pp.315-327
- DOI
- 10.14701/ahbps.2021.25.3.315
- PMID
- 34402431
- PMCID
- PMC8382872
- NLM abbreviation
- Ann Hepatobiliary Pancreat Surg
- ISSN
- 2508-5778
- eISSN
- 2508-5859
- Publisher
- The Korean Association of Hepato-Biliary-Pancreatic Surgery
- Number of pages
- 13
- Language
- English
- Date published
- 08/31/2021
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806601602771
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