Journal article
MyD88 provides a protective role in long-term radiation-induced lung injury
International journal of radiation biology, Vol.88(4), pp.335-347
04/2012
DOI: 10.3109/09553002.2012.652723
PMCID: PMC3629725
PMID: 22248128
Abstract
Purpose: The role of innate immune regulators is investigated in injury sustained from irradiation as in the clinic for cancer treatment or from a nuclear incident. The protective benefits of flagellin signaling through Toll-like receptors (TLR) in an irradiation setting warrant study of a key intracellular adaptor of TLR signaling, namely Myeloid differentiation primary response factor 88 (MyD88). The role of MyD88 in regulating innate immunity and Nuclear factor kappa-B (NF-κB)-activated responses targets this critical factor for influencing injury and recovery as well as maintaining immune homeostasis.
Materials and methods: To examine the role of MyD88, we examined immune cells and factors during acute pneumonitic and fibrotic phases in Myd88-deficient animals receiving thoracic gamma (γ)-irradiation.
Results: We found that MyD88 supports survival from radiation-induced injury through the regulation of inflammatory factors that aid in recovery from irradiation. The absence of MyD88 resulted in unresolved pulmonary infiltrate and enhanced collagen deposition plus elevated type 2 helper T cell (Th2) cytokines in long-term survivors of irradiation.
Conclusions: These results based only on a gene deletion model suggest that alterations of MyD88-dependent inflammatory processes impact chronic lung injury. Therefore, MyD88 may contribute to attenuating long-term radiation-induced lung injury and protecting against fibrosis.
Details
- Title: Subtitle
- MyD88 provides a protective role in long-term radiation-induced lung injury
- Creators
- Willie J. Brickey - University of North Carolina at Chapel HillIsabel P. Neuringer - Department of Pulmonary and Critical Care MedicineWilliam Walton - University of North Carolina at Chapel HillXiaoyang Hua - Department of Pulmonary and Critical Care MedicineEllis Y. Wang - University of North Carolina at Chapel HillSushmita Jha - University of North Carolina at Chapel HillGregory D. Sempowski - Duke Human Vaccine Institute, Duke University, North CarolinaXuebin Yang - University of North Carolina at Chapel HillSuzanne L. Kirby - University of North Carolina at Chapel HillStephen L. Tilley - Department of Pulmonary and Critical Care MedicineJenny P.-Y. Ting - University of North Carolina at Chapel Hill
- Resource Type
- Journal article
- Publication Details
- International journal of radiation biology, Vol.88(4), pp.335-347
- Publisher
- Informa Healthcare
- DOI
- 10.3109/09553002.2012.652723
- PMID
- 22248128
- PMCID
- PMC3629725
- ISSN
- 0955-3002
- eISSN
- 1362-3095
- Language
- English
- Date published
- 04/2012
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984312246902771
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