Journal article
Myasthenia gravis. Current concepts
Archives of pathology & laboratory medicine (1976), Vol.100(8), pp.401-404
08/1976
PMID: 947303
Abstract
The prevalent theory of the past two decades, that the defect in myasthenia gravis (MG) is the packaging of achetylcholine (Ach) into smaller quantal units, has recently been revised. The current theory is based on (1) electron microscopical studies of motor end plates in patients with MG; (2) radioisotope study with alpha-bungarotoxin of postsynaptic membrane Ach receptor (Ach R) sites; (3) sensitization of rabbits with the use of purified Ach R from the electric eel, inducing experimental autoimmune myasthenia gravis (EAMG); (4) detection of antibodies to the Ach R in patients with MG by radioimmunoassay; and (5) apparent induction of MG in mice by passive transfer of immunoglobulin from patients with MG. Thus, the emphasis on pathogenesis of MG is now placed on an autoimmune process involving Ach R in the subsynaptic membrane of neuromuscular junctions.
Details
- Title: Subtitle
- Myasthenia gravis. Current concepts
- Creators
- L GutmannS M Chou
- Resource Type
- Journal article
- Publication Details
- Archives of pathology & laboratory medicine (1976), Vol.100(8), pp.401-404
- Publisher
- United States
- PMID
- 947303
- ISSN
- 0003-9985
- eISSN
- 1543-2165
- Language
- English
- Date published
- 08/1976
- Academic Unit
- Neurology
- Record Identifier
- 9984020714102771
Metrics
17 Record Views