Journal article
Mycobacterium bovis Bacillus Calmette-Guérin-Induced Macrophage Cytotoxicity against Bladder Cancer Cells
Clinical & developmental immunology, Vol.2010, pp.357591-6
01/01/2010
DOI: 10.1155/2010/357591
PMCID: PMC2939389
PMID: 20862387
Abstract
Many details of the molecular and cellular mechanisms involved in
Mycobacterium bovis
bacillus Calmette-Guérin (BCG) immunotherapy of bladder cancer have been discovered in the past decades. However, information on a potential role for macrophage cytotoxicity as an effector mechanism is limited. Macrophages play pivotal roles in the host innate immunity and serve as a first line of defense in mycobacterial infection. In addition to their function as professional antigen-presenting cells, the tumoricidal activity of macrophages has also been studied with considerable interest. Studies have shown that activated macrophages are potent in killing malignant cells of various tissue origins. This review summarizes the current understanding of the BCG-induced macrophage cytotoxicity toward bladder cancer cells with an intention to inspire investigation on this important but underdeveloped research field.
Details
- Title: Subtitle
- Mycobacterium bovis Bacillus Calmette-Guérin-Induced Macrophage Cytotoxicity against Bladder Cancer Cells
- Creators
- Yi Luo - University of IowaMatthew J. Knudson - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Clinical & developmental immunology, Vol.2010, pp.357591-6
- DOI
- 10.1155/2010/357591
- PMID
- 20862387
- PMCID
- PMC2939389
- NLM abbreviation
- Clin Dev Immunol
- ISSN
- 1740-2522
- eISSN
- 1740-2530
- Publisher
- Hindawi Publishing Corporation
- Language
- English
- Date published
- 01/01/2010
- Academic Unit
- Urology
- Record Identifier
- 9984319981302771
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