Mycophenolate in dermatology

V Liu; B T Mackool

doi:10.1080/09546630310016826

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Journal article

Peer reviewed

Mycophenolate in dermatology

V Liu and B T Mackool

The Journal of dermatological treatment, Vol.14(4), pp.203-211

12/2003

DOI: 10.1080/09546630310016826

PMID: 14660264

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Abstract

Originally used to treat psoriasis nearly three decades ago, mycophenolic acid, reformulated as mycophenolate mofetil (MMF), has been rediscovered by the world of dermatology. As a relatively well-tolerated immunosuppressive used in organ transplant recipients, MMF has recently been reported to show promise for several dermatologic conditions, including psoriasis, pemphigus vulgaris, pyoderma gangrenosum, bullous lichen planus, and even connective tissue diseases such as lupus erythematosus and dermatomyositis. Although not intended to be exhaustive, this review discusses MMF with regard to its basic pharmacology, its side effects, and its reported efficacy in a variety of dermatologic indications. Relevant literature was retrieved by a Medline search combining the terms "mycophenolate" or "mycophenolic acid" and "skin" or "skin disease" or a number of specific conditions ("psoriasis", "dermatitis", "eczema", "pemphigoid", "pemphigus", "vasculitis", "pyoderma gangrenosum", "Crohn's disease", "graft-versus-host disease", "lichen planus"). As MMF has only been recently re-introduced for dermatologic application, the nature of much of the literature is admittedly that of case reports or case series. Nevertheless, the results are sufficiently promising to warrant further larger, control studies.

Eczema - drug therapy

Pyoderma Gangrenosum - drug therapy

Psoriasis - drug therapy

Drug Administration Schedule

Risk Assessment

Humans

Male

Skin Diseases - drug therapy

Treatment Outcome

Lichen Planus - drug therapy

Graft vs Host Disease

Randomized Controlled Trials as Topic

Dose-Response Relationship, Drug

Pregnancy

Mycophenolic Acid - adverse effects

Skin Diseases - diagnosis

Mycophenolic Acid - analogs & derivatives

Mycophenolic Acid - therapeutic use

Mycophenolic Acid - pharmacology

Female

Skin Diseases, Vesiculobullous - drug therapy

Details

Title: Subtitle: Mycophenolate in dermatology
Creators: V Liu - Department of Dermatology, Harvard Medical School, Massachusetts General Hospital Dermatopathology Unit, 55 Fruit Street, Boston, MA 02114, USA. bmackool@partners.org
B T Mackool
Resource Type: Journal article
Publication Details: The Journal of dermatological treatment, Vol.14(4), pp.203-211
Publisher: England
DOI: 10.1080/09546630310016826
PMID: 14660264
ISSN: 0954-6634
eISSN: 1471-1753
Language: English
Date published: 12/2003
Academic Unit: Dermatology; Pathology
Record Identifier: 9984025675202771

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