Journal article
Myeloid Slc2a1 -Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1
The Journal of immunology (1950), Vol.202(4), pp.1265-1286
02/15/2019
DOI: 10.4049/jimmunol.1800002
PMCID: PMC6360258
PMID: 30659108
Abstract
Macrophages (MΦs) are heterogeneous and metabolically flexible, with metabolism strongly affecting immune activation. A classic response to proinflammatory activation is increased flux through glycolysis with a downregulation of oxidative metabolism, whereas alternative activation is primarily oxidative, which begs the question of whether targeting glucose metabolism is a viable approach to control MΦ activation. We created a murine model of myeloid-specific glucose transporter GLUT1 (
Details
- Title: Subtitle
- Myeloid Slc2a1 -Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1
- Creators
- Alex J Freemerman - Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 25799Liyang Zhao - Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 25799Ajeeth K Pingili - Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163Bin Teng - Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163Alyssa J Cozzo - Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 25799Ashley M Fuller - Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599Amy R Johnson - Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 25799J Justin Milner - Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 25799Maili F Lim - Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 25799Joseph A Galanko - Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599Melinda A Beck - Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 25799James E Bear - Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599Jeremy D Rotty - Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599Lavanya Bezavada - Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163Heather S Smallwood - Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163Michelle A Puchowicz - Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163Juan Liu - Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Duke University, Durham, NC 27710Jason W Locasale - Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Duke University, Durham, NC 27710Douglas P Lee - Omic Insight, Inc., Durham, NC 27713Brian J Bennett - U.S. Department of Agriculture Western Human Nutrition Research Center, Davis, CA 95616E Dale Abel - Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242; andJeff C Rathmell - Department of Pathology, Microbiology, and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University, Nashville, TN 37232Liza Makowski - Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.202(4), pp.1265-1286
- DOI
- 10.4049/jimmunol.1800002
- PMID
- 30659108
- PMCID
- PMC6360258
- NLM abbreviation
- J Immunol
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Publisher
- United States
- Grant note
- S10 OD018164 / NIH HHS R01 DK105550 / NIDDK NIH HHS R00 AA017376 / NIAAA NIH HHS P30 DK056350 / NIDDK NIH HHS R01 HL128572 / NHLBI NIH HHS U01 HL087947 / NHLBI NIH HHS R01 HL136664 / NHLBI NIH HHS P30 CA016086 / NCI NIH HHS R01 GM111557 / NIGMS NIH HHS
- Language
- English
- Date published
- 02/15/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984024406502771
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