Journal article
Myocardial Collagen Concentration and Nuclear Magnetic Resonance Relaxation Times in the Spontaneously Hypertensive Rat
Investigative radiology, Vol.26(3), pp.227-232
03/1991
DOI: 10.1097/00004424-199103000-00006
PMID: 1829067
Abstract
In order to test the hypothesis that the increased myocardial collagen concentration in the older, spontaneously hypertensive (SH) rat is associated with altered T2 and Tl, we performed in vitro studies of 70 left ventricles from 8-, 22-, and 33-weck-old SH and Wistar-Kyoto (WKY) rats. We also measured the left ventricle/body weight (LV/BW) ratio (as a measure of hypertrophy), left ventricular water and fat content, and hydroxyproline concentration (as a measure of collagen). The LV/BW ratio was not significantly different between 8- week-old SH rats and WKY rats but was significantly greater in SH rats than in WKY rats at 22 and 33 weeks of age. Comparing SH rats with WKY rats at 22 weeks of age, no significant difference existed in Tl, T2, water content, or hydroxyproline concentration. However, at 33 weeks of age in SH rats compared with WKY rats, hydroxyproline concentration was significantly greater (4.3 ± 0.6 mg/g vs. 3.5 ± 0.4 mg/g, respectively; P < .0005), water content was significantly greater (77.1% ± 0.3% vs. 76.2% ± 0.3%, respectively; P < .0001), and T2 and Tl were significantly longer (T252.6 ± 2.1 msec vs. 48.6 ± 2.2 msec, respectively; P < .0001; Tl656 ± 14 msec vs. 619 ± 12 msec, respectively; P < .0001). In all SH rats combined, T2 and hydroxyproline concentration were significantly correlated (r =.63; P < .0001). Thus, in SH rats, myocardial hypertrophy precedes increased collagen deposition. These data suggest that estimation of magnetic resonance relaxation times may permit noninvasive identification of increased myocardial collagen deposition independent from changes in myocardial hypertrophy.
Details
- Title: Subtitle
- Myocardial Collagen Concentration and Nuclear Magnetic Resonance Relaxation Times in the Spontaneously Hypertensive Rat
- Creators
- MALEAH GROVER-McKAY - From the Cardiovascular Center and the Departments of Internal Medicine, The University of Iowa, Iowa City, Iowa †From the Cardiovascular Center and the Departments of Radiology, The University of Iowa, Iowa City, Iowa ‡From the Cardiovascular Center and the Departments of Pediatrics, The University of Iowa, Iowa City, Iowa §From the Cardiovascular Center and the Departments of Preventive Medicine and Environmental Health, The University of Iowa, Iowa City, Iowa ∥From the Cardiovascular Center and the Departments of Electrical and Computer Engineering, The University of Iowa, Iowa City, IowaTHOMAS SCHOLZTRUDY BURNSDAVID SKORTON
- Resource Type
- Journal article
- Publication Details
- Investigative radiology, Vol.26(3), pp.227-232
- Publisher
- Lippincott-Raven Publishers
- DOI
- 10.1097/00004424-199103000-00006
- PMID
- 1829067
- ISSN
- 0020-9996
- eISSN
- 1536-0210
- Language
- English
- Date published
- 03/1991
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Child and Community Health
- Record Identifier
- 9984093359502771
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