Myocardial Mechanics in Patients With Normal LVEF and Diastolic Dysfunction

Christopher M. Bianco; Peter D. Farjo; Yasir A. Ghaffar; Partho P. Sengupta

doi:10.1016/j.jcmg.2018.12.035

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Myocardial Mechanics in Patients With Normal LVEF and Diastolic Dysfunction

Journal article

Open access

Peer reviewed

Myocardial Mechanics in Patients With Normal LVEF and Diastolic Dysfunction

Christopher M. Bianco, Peter D. Farjo, Yasir A. Ghaffar and Partho P. Sengupta

JACC. Cardiovascular imaging, Vol.13(1), pp.258-271

01/01/2020

DOI: 10.1016/j.jcmg.2018.12.035

PMID: 31202770

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Abstract

Heart failure with preserved ejection fraction (HFpEF) is a complex clinical entity that is poorly understood yet present in up to 5.5% of the general population. Proven therapies for this disorder are lacking, even though it has a similar prognosis to that of heart failure with reduced ejection fraction (HFrEF). Innovative imaging techniques have provided in-depth understanding of the unique pattern of left ventricular mechanics in patients with HFpEF who progress through preclinical (Stages A to B) and clinical (Stages C to D) American College of Cardiology/American Heart Association heart failure stages. This review highlights the mechanical basis of this disorder from the cellular and myofiber level to chamber dysfunction. As each chamber of the heart is examined, specific biomarkers and echocardiographic parameters with diagnostic and prognostic values are discussed. Finally, novel phenotyping methods including machine learning are reviewed that integrate these mechanics into clinical groups to advise and treat patients. (C) 2020 by the American College of Cardiology Foundation.

Cardiac & Cardiovascular Systems

Cardiovascular System & Cardiology

Life Sciences & Biomedicine

Radiology, Nuclear Medicine & Medical Imaging

Science & Technology

Details

Title: Subtitle: Myocardial Mechanics in Patients With Normal LVEF and Diastolic Dysfunction
Creators: Christopher M. Bianco - West Virginia University
Peter D. Farjo - West Virginia University
Yasir A. Ghaffar - West Virginia University
Partho P. Sengupta - West Virginia University Hospitals
Resource Type: Journal article
Publication Details: JACC. Cardiovascular imaging, Vol.13(1), pp.258-271
DOI: 10.1016/j.jcmg.2018.12.035
PMID: 31202770
NLM abbreviation: JACC Cardiovasc Imaging
ISSN: 1936-878X
eISSN: 1876-7591
Publisher: Elsevier
Number of pages: 14
Language: English
Date published: 01/01/2020
Academic Unit: Internal Medicine
Record Identifier: 9984691513602771

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