Journal article
Myogenic mechanisms in the cerebral circulation
Journal of hypertension. Supplement, Vol.7(4), pp.S61-S64
09/1989
PMID: 2681598
Abstract
The autoregulatory responses of cerebral blood vessels during changes in perfusion pressure are mediated by several mechanisms. Metabolic mechanisms appear to predominate during decreases in perfusion pressure but myogenic responses can be detected under some conditions. There are major differences in the autoregulatory capacity of the cerebrum and brainstem and recent studies have suggested that the autoregulatory responses of cerebral vessels in vitro depend on the endothelium. To test this concept, we performed preliminary studies to produce selective endothelial injury of cerebral arterioles in rats, using a light-dye technique. The light-dye technique abolished the vasodilatory responses to acetylcholine and bradykinin, but the responses to adenosine and graded hypotension were preserved. These findings suggest that endothelial injury does not impair the autoregulatory responses of cerebral vessels in vivo. Calcium entry inhibitors greatly impair the autoregulatory responses of cerebral vessels, which suggests that entry of extracellular calcium is essential for cerebral autoregulation. Chronic hypertension alters cerebral autoregulation and may produce 'remodelling,' so that autoregulatory constriction is increased.
Details
- Title: Subtitle
- Myogenic mechanisms in the cerebral circulation
- Creators
- F M Faraci - University of Iowa College of Medicine, Depatment of Internal Medicine, Iowa City 52242G L BaumbachD D Heistad
- Resource Type
- Journal article
- Publication Details
- Journal of hypertension. Supplement, Vol.7(4), pp.S61-S64
- Publisher
- England
- PMID
- 2681598
- ISSN
- 0952-1178
- eISSN
- 1473-5598
- Grant note
- NS 24621 / NINDS NIH HHS HL 38901 / NHLBI NIH HHS HL 16066 / NHLBI NIH HHS
- Language
- English
- Date published
- 09/1989
- Academic Unit
- Pathology; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040493902771
Metrics
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