Journal article
Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway
Cancer letters, Vol.308(2), pp.181-188
09/28/2011
DOI: 10.1016/j.canlet.2011.05.002
PMID: 21676539
Abstract
Pancreatic cancer is the fourth leading cause of cancer related deaths and is a disease with poor prognosis. It is refractory to standard chemotherapeutic drugs or to novel treatment modalities, making it imperative to find new treatments. In this study, using both primary and metastatic pancreatic cancer cell lines, we have demonstrated that the flavonoid myricetin induced pancreatic cancer cell death in vitro via apoptosis, and caused a decrease in PI3 kinase activity. In vivo, treatment of orthotopic pancreatic tumors with myricetin resulted in tumor regression and decreased metastatic spread. Importantly, myricetin was non-toxic, both in vitro and in vivo, underscoring its use as a therapeutic agent against pancreatic cancer. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Details
- Title: Subtitle
- Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway
- Creators
- P. A. Phillips - University of MinnesotaV. Sangwan - University of MinnesotaD. Borja-Cacho - University of MinnesotaV. Dudeja - University of MinnesotaS. M. Vickers - University of MinnesotaA. K. Saluja - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- Cancer letters, Vol.308(2), pp.181-188
- DOI
- 10.1016/j.canlet.2011.05.002
- PMID
- 21676539
- NLM abbreviation
- Cancer Lett
- ISSN
- 0304-3835
- eISSN
- 1872-7980
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- DK-58694; CA-124723 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Cancer Institute NSW
- Language
- English
- Date published
- 09/28/2011
- Academic Unit
- Anatomy and Cell Biology; Surgery
- Record Identifier
- 9985244676002771
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