NAD as a genotype-specific drug target

Szu-Chieh Mei; Charles Brenner

doi:10.1016/j.chembiol.2013.11.001

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NAD as a genotype-specific drug target

Szu-Chieh Mei and Charles Brenner

Chemistry & biology, Vol.20(11), pp.1307-1308

11/21/2013

DOI: 10.1016/j.chembiol.2013.11.001

PMCID: PMC3907267

PMID: 24267273

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Abstract

Using high-throughput chemical and genetic screening, Matheny and colleagues (in this issue of Chemistry & Biology) identified STF-118804, an inhibitor of nicotinamide phosphoribosyltransferase, as a cell type-specific inhibitor of mixed-lineage leukemia with MLL chromosomal rearrangements. The approach was powerful, as is the potential for NAD as a specific cancer target.

Picolines - pharmacology

Animals

Humans

Enzyme Inhibitors - pharmacology

Male

Antineoplastic Agents - pharmacology

Benzamides - pharmacology

Cytokines - antagonists & inhibitors

Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors

Details

Title: Subtitle: NAD as a genotype-specific drug target
Creators: Szu-Chieh Mei - Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Charles Brenner
Resource Type: Journal article
Publication Details: Chemistry & biology, Vol.20(11), pp.1307-1308
DOI: 10.1016/j.chembiol.2013.11.001
PMID: 24267273
PMCID: PMC3907267
NLM abbreviation: Chem Biol
ISSN: 1074-5521
eISSN: 1879-1301
Publisher: United States
Grant note: R01 CA148629 / NCI NIH HHS
Language: English
Date published: 11/21/2013
Academic Unit: Biochemistry and Molecular Biology; Internal Medicine
Record Identifier: 9983788600002771

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