Journal article
NAD+ metabolism in health and disease
Trends in biochemical sciences, Vol.32(1), pp.12-19
01/2007
DOI: 10.1016/j.tibs.2006.11.006
PMID: 17161604
Abstract
Nicotinamide adenine dinucleotide (NAD(+)) is both a coenzyme for hydride-transfer enzymes and a substrate for NAD(+)-consuming enzymes, which include ADP-ribose transferases, poly(ADP-ribose) polymerases, cADP-ribose synthases and sirtuins. Recent results establish protective roles for NAD(+) that might be applicable therapeutically to prevent neurodegenerative conditions and to fight Candida glabrata infection. In addition, the contribution that NAD(+) metabolism makes to lifespan extension in model systems indicates that therapies to boost NAD(+) might promote some of the beneficial effects of calorie restriction. Nicotinamide riboside, the recently discovered nucleoside precursor of NAD(+) in eukaryotic systems, might have advantages as a therapy to elevate NAD(+) without inhibiting sirtuins, which is associated with high-dose nicotinamide, or incurring the unpleasant side-effects of high-dose nicotinic acid.
Details
- Title: Subtitle
- NAD+ metabolism in health and disease
- Creators
- Peter Belenky - Departments of Genetics and of Biochemistry and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USAKatrina L BoganCharles Brenner
- Resource Type
- Journal article
- Publication Details
- Trends in biochemical sciences, Vol.32(1), pp.12-19
- Publisher
- England
- DOI
- 10.1016/j.tibs.2006.11.006
- PMID
- 17161604
- ISSN
- 0968-0004
- eISSN
- 1362-4326
- Language
- English
- Date published
- 01/2007
- Academic Unit
- Biochemistry and Molecular Biology; Internal Medicine
- Record Identifier
- 9983788429002771
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