Journal article
NK Cell-Derived IL-10 Supports Host Survival during Sepsis
The Journal of immunology (1950), Vol.206(6), pp.1171-1180
03/15/2021
DOI: 10.4049/jimmunol.2001131
PMCID: PMC7946778
PMID: 33514512
Abstract
The dysregulated sepsis-induced cytokine storm evoked during systemic infection consists of biphasic and interconnected pro- and anti-inflammatory responses. The contrasting inflammatory cytokine responses determine the severity of the septic event, lymphopenia, host survival, and the ensuing long-lasting immunoparalysis state. NK cells, because of their capacity to elaborate pro- (i.e., IFN-γ) and anti-inflammatory (i.e., IL-10) responses, exist at the inflection of sepsis-induced inflammatory responses. Thus, NK cell activity could be beneficial or detrimental during sepsis. In this study, we demonstrate that murine NK cells promote host survival during sepsis by limiting the scope and duration of the cytokine storm. Specifically, NK cell-derived IL-10, produced in response to IL-15, is relevant to clinical manifestations in septic patients and critical for survival during sepsis. This role of NK cells demonstrates that regulatory mechanisms of classical inflammatory cells are beneficial and critical for controlling systemic inflammation, a notion relevant for therapeutic interventions during dysregulated infection-induced inflammatory responses.
Details
- Title: Subtitle
- NK Cell-Derived IL-10 Supports Host Survival during Sepsis
- Creators
- Isaac J Jensen - University of IowaPatrick W McGonagill - University of IowaNoah S Butler - University of IowaJohn T Harty - University of IowaThomas S Griffith - University of MinnesotaVladimir P Badovinac - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.206(6), pp.1171-1180
- DOI
- 10.4049/jimmunol.2001131
- PMID
- 33514512
- PMCID
- PMC7946778
- NLM abbreviation
- J Immunol
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Grant note
- I01 BX001324 / BLRD VA R21 AI147064 / NIAID NIH HHS R01 AI114543 / NIAID NIH HHS R35 GM134880 / NIGMS NIH HHS R01 AI100527 / NIAID NIH HHS R01 AI127481 / NIAID NIH HHS R21 AI151183 / NIAID NIH HHS R01 AI042767 / NIAID NIH HHS T32 AI007511 / NIAID NIH HHS T32 AI007485 / NIAID NIH HHS R01 AI085515 / NIAID NIH HHS R01 AI125446 / NIAID NIH HHS R01 GM115462 / NIGMS NIH HHS
- Language
- English
- Date published
- 03/15/2021
- Academic Unit
- Molecular Physiology and Biophysics; Microbiology and Immunology; Pathology; Surgery
- Record Identifier
- 9984181068302771
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