Journal article
NK cells in allogeneic bone marrow transplantation
Cancer immunology, immunotherapy : CII, Vol.52(9), pp.525-534
09/01/2003
DOI: 10.1007/s00262-003-0378-7
PMCID: PMC11034224
PMID: 14627124
Abstract
NK cells, until recently an ignored subset of lymphocytes, have begun to emerge as important cytotoxic effectors. It is now accepted that NK cells together with T cells constitute major actors in graft-versus-leukemia reaction after allogeneic bone marrow transplantation (BMT). Over the last several years the mechanisms regulating the activation of NK cells have been the subject of intense investigations encouraged by the clinical implications that these studies will have. This article provides a general overview of NK-cells biology and regulation pertinent to their function in allogeneic BMT, followed by a review of the in vivo preclinical and clinical evidence for the beneficial effect of NK cells in the adoptive immunotherapy of leukemia.
Details
- Title: Subtitle
- NK cells in allogeneic bone marrow transplantation
- Creators
- Ioannis A Voutsadakis - Institut Gustave Roussy
- Resource Type
- Journal article
- Publication Details
- Cancer immunology, immunotherapy : CII, Vol.52(9), pp.525-534
- DOI
- 10.1007/s00262-003-0378-7
- PMID
- 14627124
- PMCID
- PMC11034224
- NLM abbreviation
- Cancer Immunol Immunother
- ISSN
- 0340-7004
- eISSN
- 1432-0851
- Language
- English
- Date published
- 09/01/2003
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806614002771
Metrics
6 Record Views