Journal article
NMR relaxation times in acute myocardial infarction: Relative influence of changes in tissue water and fat content
Magnetic resonance in medicine, Vol.23(1), pp.89-95
01/1992
DOI: 10.1002/mrm.1910230110
PMID: 1734185
Abstract
Tissue changes known to occur with acute myocardial infarction include increases in tissue water and lipid content. We sought to evaluate the relative contribution of alterations in tissue water and fat content to the changes of T1 and T2 relaxation times with infarction. Nine mongrel dogs underwent coronary artery occlusion for 6-12 h. T1 and T2 at 20 MHz and tissue water and fat content of normal and infarcted tissue were measured. Tissue water content, T1, and T2 were significantly greater in infarcted myocardium compared to normal (P less than 0.05). Tissue fat content, while not significantly different, increased linearly in infarcted samples as a function of duration of ischemia (r = 0.77). Despite this increase in fat content, only tissue water content was significantly linearly related to T1 (r = 0.97) and T2 (r = 0.91). Increases in T1 and T2 of infarcted tissue appeared to be most significantly influenced by changes in tissue water content. While total tissue fat content increased with duration of ischemia, it did not appear to significantly alter T1 or T2.
Details
- Title: Subtitle
- NMR relaxation times in acute myocardial infarction: Relative influence of changes in tissue water and fat content
- Creators
- Thomas D Scholz - The Cardiovascular Center and Departments of Pediatrics, Internal Medicine, and Electrical and Computer Engineering, The University of Iowa, Iowa City, Iowa 52242James B Martins - The Cardiovascular Center and Departments of Pediatrics, Internal Medicine, and Electrical and Computer Engineering, The University of Iowa, Iowa City, Iowa 52242David J Skorton - The Cardiovascular Center and Departments of Pediatrics, Internal Medicine, and Electrical and Computer Engineering, The University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.23(1), pp.89-95
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/mrm.1910230110
- PMID
- 1734185
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Number of pages
- 7
- Language
- English
- Date published
- 01/1992
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center; Child and Community Health; Internal Medicine
- Record Identifier
- 9984093504502771
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