NOTCH4 and the frontal lobe in schizophrenia

Thomas H Wassink; Peggy Nopoulos; Jennifer Pietila; Raymond R Crowe; Nancy C Andreasen

doi:10.1002/ajmg.b.10071

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NOTCH4 and the frontal lobe in schizophrenia

Journal article

Peer reviewed

NOTCH4 and the frontal lobe in schizophrenia

Thomas H Wassink, Peggy Nopoulos, Jennifer Pietila, Raymond R Crowe and Nancy C Andreasen

American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.118B(1), pp.1-7

04/01/2003

DOI: 10.1002/ajmg.b.10071

PMID: 12627456

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Abstract

NOTCH4 is a developmentally expressed gene recently reported to be in linkage disequilibrium (LD) with schizophrenia. We investigated this finding in our sample of subjects, focusing on an exonic (CTG)(n) polymorphism, examining not only the association of this polymorphism with the disease phenotype, but also its effect on frontal lobe brain morphology and cognitive function in both affected individuals and a psychiatrically normal comparison group. While we did not find any association or LD with schizophrenia, we identified striking effects of NOTCH4 variability on the trait measures. Within the respective schizophrenia and comparison groups, NOTCH4 allelic variability was correlated with differences in measures of frontal lobe cognitive performance and frontal lobe brain tissue volumes that were intuitively congruent. These within-group effects, however, were in opposite directions across groups. These findings may reflect the interaction of NOTCH4 with the underlying genetic and phenotypic complexity that characterizes both schizophrenia and normal cognition and brain development.

Gene Frequency

Humans

Male

Proto-Oncogene Proteins - genetics

Receptors, Cell Surface

Schizophrenia - pathology

Schizophrenic Psychology

Trinucleotide Repeats - genetics

Linkage Disequilibrium

Polymorphism, Genetic

DNA - genetics

Neuropsychological Tests

Receptors, Notch

Schizophrenia - genetics

Analysis of Variance

Alleles

Adult

Female

Frontal Lobe - pathology

Receptor, Notch4

Details

Title: Subtitle: NOTCH4 and the frontal lobe in schizophrenia
Creators: Thomas H Wassink - Department of Psychiatry, Psychiatry Research/MEB, University of Iowa College of Medicine, Iowa City, IA 52242, USA. thomas-wassink@uiowa.edu
Peggy Nopoulos
Jennifer Pietila
Raymond R Crowe
Nancy C Andreasen
Resource Type: Journal article
Publication Details: American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.118B(1), pp.1-7
DOI: 10.1002/ajmg.b.10071
PMID: 12627456
NLM abbreviation: Am J Med Genet B Neuropsychiatr Genet
ISSN: 1552-4841
eISSN: 1552-485X
Publisher: United States
Grant note: MH 43271 / NIMH NIH HHS MH 40856 / NIMH NIH HHS MH 31593 / NIMH NIH HHS MH 43212 / NIMH NIH HHS MH 00735 / NIMH NIH HHS
Language: English
Date published: 04/01/2003
Academic Unit: Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
Record Identifier: 9984004096002771

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