Journal article
NOX4 expression and distal arteriolar remodeling correlate with pulmonary hypertension in COPD
BMC pulmonary medicine, Vol.18(1), pp.111-111
07/09/2018
DOI: 10.1186/s12890-018-0680-y
PMCID: PMC6038356
PMID: 29986678
Abstract
Background: Pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) is suggested as the consequence of emphysematous destruction of vascular bed and hypoxia of pulmonary microenvironment, mechanisms underpinning its pathogenesis however remain elusive. The dysregulated expression of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidases and superoxide generation by pulmonary vasculatures have significant implications in the hypoxia-induced PH. Methods: In this study, the involvement of NADPH oxidase subunit 4 (NOX4) in pulmonary arteriolar remodeling of PH in COPD was investigated by ascertaining the morphological alteration of pulmonary arteries and pulmonary blood flow using cardiac magnetic resonance imaging (cMRI), and the expression and correlation of NOX4 with pulmonary vascular remodeling and pulmonary functions in COPD lungs. Results: Results demonstrated that an augmented expression of NOX4 was correlated with the increased volume of pulmonary vascular wall in COPD lung. While the volume of distal pulmonary arteries was inversely correlated with pulmonary functions, despite it was positively associated with the main pulmonary artery distensibility, right ventricular myocardial mass end-systolic and right ventricular myocardial mass end-diastolic in COPD. In addition, an increased malondialdehyde and a decreased superoxide dismutase were observed in sera of COPD patients. Mechanistically, the abundance of NOX4 and production of reactive oxygen species (ROS) in pulmonary artery smooth muscle cells could be dynamically induced by transforming growth factor-beta (TGF-β), which in turn led pulmonary arteriolar remodeling in COPD lungs. Conclusion: These results suggest that the NOX4-derived ROS production may play a key role in the development of PH in COPD by promoting distal pulmonary vascular remodeling.
Details
- Title: Subtitle
- NOX4 expression and distal arteriolar remodeling correlate with pulmonary hypertension in COPD
- Creators
- Xiaotong Guo - 804 Shengli South Street, Xingqing District, Yinchuan, Ningxia 750004 People’s Republic of ChinaYuchun Fan - 804 Shengli South Street, Xingqing District, Yinchuan, Ningxia 750004 People’s Republic of ChinaJieda Cui - 804 Shengli South Street, Xingqing District, Yinchuan, Ningxia 750004 People’s Republic of ChinaBinwei Hao - 804 Shengli South Street, Xingqing District, Yinchuan, Ningxia 750004 People’s Republic of ChinaLi Zhu - Yinchuan, 750004 Ningxia ChinaXiao Sun - Yinchuan, 750004 Ningxia ChinaJinxi He - Yinchuan, 750004 Ningxia ChinaJiali Yang - Yinchuan, 750004 Ningxia ChinaJianda Dong - Yinchuan, 750004 Ningxia ChinaYanyang Wang - Yinchuan, 750004 Ningxia ChinaXiaoming Liu - 804 Shengli South Street, Xingqing District, Yinchuan, Ningxia 750004 People’s Republic of ChinaJuan Chen - 804 Shengli South Street, Xingqing District, Yinchuan, Ningxia 750004 People’s Republic of China
- Resource Type
- Journal article
- Publication Details
- BMC pulmonary medicine, Vol.18(1), pp.111-111
- DOI
- 10.1186/s12890-018-0680-y
- PMID
- 29986678
- PMCID
- PMC6038356
- NLM abbreviation
- BMC Pulm Med
- ISSN
- 1471-2466
- eISSN
- 1471-2466
- Publisher
- BioMed Central; London
- Grant note
- YXW 2017014 / ; 2015s / ; 81360004; 81760004; 31472191 / ; XY201702 / ;
- Language
- English
- Date published
- 07/09/2018
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9984025413502771
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