Journal article
NTS Catecholamine Neurons Mediate Hypoglycemic Hunger via Medial Hypothalamic Feeding Pathways
Cell metabolism, Vol.31(2), pp.313-326.e5
02/04/2020
DOI: 10.1016/j.cmet.2019.11.016
PMID: 31839488
Abstract
Glucose is the essential energy source for the brain, whose deficit, triggered by energy deprivation or therapeutic agents, can be fatal. Increased appetite is the key behavioral defense against hypoglycemia; however, the central pathways involved are not well understood. Here, we describe a glucoprivic feeding pathway by tyrosine hydroxylase (TH)-expressing neurons from nucleus of solitary tract (NTS), which project densely to the hypothalamus and elicit feeding through bidirectional adrenergic modulation of agouti-related peptide (AgRP)- and proopiomelanocortin (POMC)-expressing neurons. Acute chemogenetic inhibition of arcuate nucleus (ARC)-projecting NTSTH neurons or their target, AgRP neurons, impaired glucoprivic feeding induced by 2-Deoxy-D-glucose (2DG) injection. Neuroanatomical tracing results suggested that ARC-projecting orexigenic NTSTH neurons are largely distinct from neighboring catecholamine neurons projecting to parabrachial nucleus (PBN) that promotes satiety. Collectively, we describe a circuit organization in which an ascending pathway from brainstem stimulates appetite through key hunger neurons in the hypothalamus in response to hypoglycemia.
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•NTSTH axons innervate the ARC and elicit food intake via norepinephrine release•ARC-projecting NTSTH neurons are required for glucoprivic feeding•AgRP neurons are targeted by NTSTH axons and contribute to glucoprivic feeding•ARC- and PBN-projecting NTSTH neurons are largely distinct
Increased appetite is a key line of defense against hypoglycemia. Aklan et al. have identified an ascending pathway from the brainstem to the hypothalamus that is required for hypoglycemia-induced food intake.
Details
- Title: Subtitle
- NTS Catecholamine Neurons Mediate Hypoglycemic Hunger via Medial Hypothalamic Feeding Pathways
- Creators
- Iltan Aklan - Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USANilufer Sayar Atasoy - Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USAYavuz Yavuz - Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USATayfun Ates - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyIlknur Coban - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyFulya Koksalar - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyGizem Filiz - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyIskalen Cansu Topcu - Department of Physiology, School of Medicine, Yeditepe University, Istanbul, TurkeyMerve Oncul - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyPelin Dilsiz - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyUtku Cebecioglu - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyMuhammed Ikbal Alp - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyBayram Yilmaz - Department of Physiology, School of Medicine, Yeditepe University, Istanbul, TurkeyDeborah R Davis - Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USAKarolina Hajdukiewicz - Laboratory of Animal Models, Neurobiology Center, Nencki Institute of Experimental Biology, Warsaw, PolandKenji Saito - Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USAWitold Konopka - Laboratory of Animal Models, Neurobiology Center, Nencki Institute of Experimental Biology, Warsaw, PolandHuxing Cui - Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USADeniz Atasoy - Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Cell metabolism, Vol.31(2), pp.313-326.e5
- DOI
- 10.1016/j.cmet.2019.11.016
- PMID
- 31839488
- NLM abbreviation
- Cell Metab
- ISSN
- 1550-4131
- eISSN
- 1932-7420
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100002069, name: Fraternal Order of Eagles; DOI: 10.13039/501100003043, name: EMBO
- Language
- English
- Date published
- 02/04/2020
- Academic Unit
- Pathology; Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984065878002771
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