Journal article
Naive, effector and memory CD8 T-cell trafficking: parallels and distinctions
Immunotherapy, Vol.3(10), pp.1223-1233
10/2011
DOI: 10.2217/imt.11.100
PMCID: PMC3214994
PMID: 21995573
Abstract
Trafficking of CD8 T cells, in both the steady-state and during episodes of infection or inflammation, is a highly dynamic process and involves a variety of receptor-ligand interactions. A thorough, mechanistic understanding of how this process is regulated could potentially lead to disease prevention strategies, through either enhancing (for infectious diseases or tumors) or limiting (for autoimmunity) recruitment of antigen-specific CD8 T cells to areas of tissue inflammation. As CD8 T cells transition from naive to effector to memory cells, changes in gene expression will ultimately dictate anatomical localization of these cells
in vivo
. In this article, we discuss recent advances in understanding how antigenic stimulation influences expression of various trafficking receptors and ligands, and how this determines the tissue localization of CD8 T cells.
Details
- Title: Subtitle
- Naive, effector and memory CD8 T-cell trafficking: parallels and distinctions
- Creators
- Jeffrey C Nolz - Department of Microbiology, 3-512 Bowen Science Building, 51 Newton Rd, Iowa City, IA 52242, USAGabriel R Starbeck-Miller - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USAJohn T Harty - Department of Microbiology, 3-512 Bowen Science Building, 51 Newton Rd, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Immunotherapy, Vol.3(10), pp.1223-1233
- DOI
- 10.2217/imt.11.100
- PMID
- 21995573
- PMCID
- PMC3214994
- NLM abbreviation
- Immunotherapy
- ISSN
- 1750-743X
- eISSN
- 1750-7448
- Grant note
- R01 AI085515-03 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R37 AI042767-14 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R01 AI059752-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R01 AI050073-10 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R01 AI046653-10 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID
- Language
- English
- Date published
- 10/2011
- Academic Unit
- Pathology
- Record Identifier
- 9984047766502771
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