Journal article
Nano-enabled delivery of diverse payloads across complex biological barriers
Journal of controlled release, Vol.219, pp.548-559
12/10/2015
DOI: 10.1016/j.jconrel.2015.08.039
PMCID: PMC4656048
PMID: 26315817
Abstract
Complex biological barriers are major obstacles for preventing and treating disease. Nanocarriers are designed to overcome such obstacles by enhancing drug delivery through physiochemical barriers and improving therapeutic indices. This review critically examines both biological barriers and nanocarrier payloads for a variety of drug delivery applications. A spectrum of nanocarriers is discussed that have been successfully developed for improving tissue penetration for preventing or treating a range of infectious, inflammatory, and degenerative diseases. Nanocarriers functionalized with active and passive targeting strategies enable the efficient delivery of diverse payloads through complex biological barriers to prevent and treat vector-borne diseases, neuronal disorders, and cancer. [Display omitted]
Details
- Title: Subtitle
- Nano-enabled delivery of diverse payloads across complex biological barriers
- Creators
- Kathleen A Ross - Chemical and Biological Engineering, Iowa State University, 2114 Sweeney Hall, Ames 50011, USATimothy M Brenza - Chemical and Biological Engineering, Iowa State University, 2114 Sweeney Hall, Ames 50011, USAAndrea M Binnebose - Veterinary Microbiology and Preventive Medicine, Iowa State University, 2180 Vet Med, Ames 50011, USAYashdeep Phanse - Pathobiological Sciences, University of Wisconsin-Madison, 1656 Linden Dr., Madison 53706, USAAnumantha G Kanthasamy - Biomedical Sciences, Iowa State University, 2008 Vet Med, Ames 50011, USAHoward E Gendelman - Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha 68198, USAAliasger K Salem - Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa, 115 S. Grand Avenue, Iowa City 52242, USALyric C Bartholomay - Pathobiological Sciences, University of Wisconsin-Madison, 1656 Linden Dr., Madison 53706, USABryan H Bellaire - Veterinary Microbiology and Preventive Medicine, Iowa State University, 2180 Vet Med, Ames 50011, USABalaji Narasimhan - Chemical and Biological Engineering, Iowa State University, 2114 Sweeney Hall, Ames 50011, USA
- Resource Type
- Journal article
- Publication Details
- Journal of controlled release, Vol.219, pp.548-559
- DOI
- 10.1016/j.jconrel.2015.08.039
- PMID
- 26315817
- PMCID
- PMC4656048
- NLM abbreviation
- J Control Release
- ISSN
- 0168-3659
- eISSN
- 1873-4995
- Publisher
- Elsevier B.V
- Grant note
- DOI: 10.13039/100000182, name: U.S. Army Medical Center and Materiel Command, award: W81-XWH-11-10700; DOI: 10.13039/100000865, name: Bill and Melinda Gates Foundation Grand Challenges Exploration, award: OPP 1087610; DOI: 10.13039/100009227, name: Iowa State Nanovaccine Initiative; DOI: 10.13039/100000182, name: U.S. Army Medical Center and Materiel Command, award: W81-XWH-11-10700; DOI: 10.13039/100000002, name: National Institutes of Health, award: NS 074443; DOI: 10.13039/100000002, name: National Institutes of Health, award: 5R01 AG043540-02, P01 DA028555, R01 NS36126, 2R01 NS034239, P30 MH062261; DOI: 10.13039/100000054, name: National Cancer Institute at the National Institutes of Health, award: P50 CA97274, P30 CA086862; DOI: 10.13039/100000002, name: Foundation for the National Institutes of Health; DOI: 10.13039/100009227, name: Iowa State Nanovaccine Initiative; DOI: 10.13039/100000865, name: Bill and Melinda Gates Foundation Grand Challenges Exploration, award: OPP 1087610; DOI: 10.13039/100009227, name: Iowa State Nanovaccine Initiative
- Language
- English
- Date published
- 12/10/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Epidemiology; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering
- Record Identifier
- 9983985960102771
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