Journal article
Nanoclay-functionalized 3D nanofibrous scaffolds promote bone regeneration
Journal of materials chemistry. B, Materials for biology and medicine, Vol.8(17), pp.3842-3851
05/07/2020
DOI: 10.1039/c9tb02814e
PMID: 32219244
Abstract
Developing a biomaterial that can promote osteoblastic differentiation, thereby reducing the needs of exogenous osteogenic factors for large bone repair, has been a significant and long-term technical hurdle. In this study, we developed an innovative nanoclay (nanosilicate, NS)-functionalized 3D gelatin nanofibrous scaffold (GF/NS) through a thermally induced phase separation method together with the particle leaching technique (TIPS&P). In addition to the significantly higher mechanical strength, the composite scaffolds (GF/NS) demonstrated a significantly stronger ability to promote the osteogenic differentiation of human mesenchymal stem cells (hMSCs) in vitro compared to the GF scaffold. Our data further revealed that this intriguing pro-osteoblastic functionality was largely because of the unique features of NS, particularly, the strong binding ability to pro-osteoblastic factors (e.g., BMP2) as well as the intrinsic osteoinductivity of its bioactive degradation products. Most importantly, our in vivo studies indicated that GF/NS scaffolds significantly improved low-dose BMP2-induced ectopic bone regeneration in mice.
Details
- Title: Subtitle
- Nanoclay-functionalized 3D nanofibrous scaffolds promote bone regeneration
- Creators
- Qingqing Yao - Wenzhou Medical UniversityKirby E. Fuglsby - University of South DakotaXiao Zheng - Wenzhou Medical UniversityHongli Sun - University of South Dakota
- Resource Type
- Journal article
- Publication Details
- Journal of materials chemistry. B, Materials for biology and medicine, Vol.8(17), pp.3842-3851
- DOI
- 10.1039/c9tb02814e
- PMID
- 32219244
- NLM abbreviation
- J Mater Chem B
- ISSN
- 2050-750X
- eISSN
- 2050-7518
- Publisher
- Royal Soc Chemistry
- Number of pages
- 10
- Grant note
- 31600773 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) Department of Biomedical Engineering, University of South Dakota
- Language
- English
- Date published
- 05/07/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Craniofacial Anomalies Research Center; Oral and Maxillofacial Surgery
- Record Identifier
- 9984367744502771
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