Journal article
Nanomedicines for Targeted Pulmonary Delivery: Receptor-Mediated Strategy and Alternatives
Nanoscale, Vol.16(6), pp.2820-2833
2024
DOI: 10.1039/D3NR05487J
PMID: 38289362
Abstract
Pulmonary drug delivery of nanomedicines is promising for lung disease treatment whereas lack of the specificity required for targeted delivery limit their applications. Recently, varieties of pulmonary delivery targeting nanomedicines (PDTNs) were developed for enhancing the drug accumulation in lung lesions and reducing systematical side effects. As the profound understanding the specific microenvironment of different lung local diseases, multiple targeting strategies have been employed to promote drug delivery efficiency, which could be divided as receptor-mediated strategy and alternatives. In this review, the current publication trend of PDTNs were analyzed and discussed, which reveals research in this area has been gaining traction. According to the different unique microenvironment of lung lesions, the reported PDTNs based on receptor-mediated strategy for lung cancer, lung infection, lung inflammation and pulmonary fibrosis were listed and summarized. Several other well-established strategies for the design of these PDTNs such as charge regulation, mucus delivery enhancement, stimuli-responsive drug delivery, and magnetic force-driven targeting were introduced and discussed. Besides, the bottlenecks in the development of PDTNs will be discussed. Finally, this review will highlight the challenges and opportunities in the development of PDTNs. We hope this review will provide a guiding overview of the PDTNs for the treatment of lung diseases.
Details
- Title: Subtitle
- Nanomedicines for Targeted Pulmonary Delivery: Receptor-Mediated Strategy and Alternatives
- Creators
- Wenhao Wang - Sun Yat-sen UniversityZiqiao Zhong - Jinan UniversityZhengwei Huang - Jinan UniversityTze Ning Hiew - University of IowaYing Huang - Jinan UniversityChuanbin Wu - Jinan UniversityXin Pan - Sun Yat-sen University
- Resource Type
- Journal article
- Publication Details
- Nanoscale, Vol.16(6), pp.2820-2833
- DOI
- 10.1039/D3NR05487J
- PMID
- 38289362
- NLM abbreviation
- Nanoscale
- ISSN
- 2040-3364
- eISSN
- 2040-3372
- Grant note
- DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 81703431, 81673375, 82104070, 82073774
- Language
- English
- Electronic publication date
- 2024
- Date published
- 2024
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984548665502771
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