Journal article
Nanoparticle aerosol generation methods from bulk powders for inhalation exposure studies
Nanotoxicology, Vol.3(4), pp.265-275
12/01/2009
DOI: 10.3109/17435390903121931
Abstract
Inhalation toxicity studies of nanoparticles require production of test aerosols with a number of acceptable characteristics. Five different generation methods for producing a nanoparticle aerosol from the bulk powder were evaluated with the goal of producing an acceptable aerosol that is homogenous, has a consistent concentration over time in which the magnitude may be intentionally varied, and has a size distribution that is both unimodal and has a small geometric mean diameter relative to the primary particle size of the nanoparticle bulk powder. Four types of bulk powders were evaluated including titanium dioxide, silicon dioxide, polymer-coated silver, and single walled carbon nanotubes. A nebulizer was the only tested method able to produce a consistent aerosol of sufficient magnitude. However, the resulting aerosol contains particles derived from the carrier water. Prior sonication of the nanoparticle suspension alone was found to be not useful for deagglomerating nanoparticles.
Details
- Title: Subtitle
- Nanoparticle aerosol generation methods from bulk powders for inhalation exposure studies
- Creators
- Linda H SchmollSherrie ElzeyVicki H GrassianPatrick T O'Shaughnessy
- Resource Type
- Journal article
- Publication Details
- Nanotoxicology, Vol.3(4), pp.265-275
- Publisher
- Taylor & Francis
- DOI
- 10.3109/17435390903121931
- ISSN
- 1743-5390
- eISSN
- 1743-5404
- Language
- English
- Date published
- 12/01/2009
- Academic Unit
- Occupational and Environmental Health; Chemical and Biochemical Engineering; Civil and Environmental Engineering; Chemistry
- Record Identifier
- 9984213369602771
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