Journal article
Nanoparticle based delivery of CRISPR/Cas9 genome editing therapeutics
The AAPS journal, Vol.20(6), pp.108-108
2018
DOI: 10.1208/s12248-018-0267-9
PMID: 30306365
Abstract
The recent progress in harnessing the efficient and precise method of DNA editing provided by CRISPR/Cas9 is one of the most promising major advances in the field of gene therapy. However, the development of safe and optimally efficient delivery systems for CRISPR/Cas9 elements capable of achieving specific targeting of gene therapy to the location of interest without off-target effects is a primary challenge for clinical therapeutics. Nanoparticles (NPs) provide a promising means to meet such challenges. In this review, we present the most recent advances in developing innovative NP-based delivery systems that efficiently deliver CRISPR-Cas9 constructs and maximize their effectiveness.
Details
- Title: Subtitle
- Nanoparticle based delivery of CRISPR/Cas9 genome editing therapeutics
- Creators
- Brittany E Givens - Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City IA 52242, USAYoussef W Naguib - Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City IA 52242, USASean M Geary - Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City IA 52242, USAEric J Devor - Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City IA 52242, USAAliasger K Salem - Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- The AAPS journal, Vol.20(6), pp.108-108
- DOI
- 10.1208/s12248-018-0267-9
- PMID
- 30306365
- NLM abbreviation
- AAPS J
- ISSN
- 1550-7416
- eISSN
- 1550-7416
- Language
- English
- Date published
- 2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Obstetrics and Gynecology; Dental Research; Chemical and Biochemical Engineering
- Record Identifier
- 9983930280602771
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