Journal article
Nanoparticle-based monitoring of cell therapy
Nanotechnology, Vol.22(49), pp.494001-494001
12/09/2011
DOI: 10.1088/0957-4484/22/49/494001
PMCID: PMC3334527
PMID: 22101191
Abstract
Exogenous cell therapy aims to replace/repair diseased or dysfunctional cells and promises to revolutionize medicine by restoring tissue and organ function. To develop effective cell therapy, the location, distribution and long-term persistence of transplanted cells must be evaluated. Nanoparticle (NP) based imaging technologies have the potential to track transplanted cells non-invasively. Here we summarize the most recent advances in NP-based cell tracking with emphasis on (1) the design criteria for cell tracking NPs, (2) protocols for cell labeling, (3) a comparison of available imaging modalities and their corresponding contrast agents, (4) a summary of preclinical studies on NP-based cell tracking and finally (5) perspectives and future directions.
Details
- Title: Subtitle
- Nanoparticle-based monitoring of cell therapy
- Creators
- Chenjie Xu - Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USALuye Mu - Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USAIsaac Roes - Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USADavid Miranda-Nieves - Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USAMatthias Nahrendorf - Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USAJames A Ankrum - Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USAWeian Zhao - Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USAJeffrey M Karp - Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
- Resource Type
- Journal article
- Publication Details
- Nanotechnology, Vol.22(49), pp.494001-494001
- DOI
- 10.1088/0957-4484/22/49/494001
- PMID
- 22101191
- PMCID
- PMC3334527
- NLM abbreviation
- Nanotechnology
- ISSN
- 0957-4484
- eISSN
- 1361-6528
- Grant note
- R01 HL095722-01A2 || HL / National Heart, Lung, and Blood Institute : NHLBI R21 HL097172-02 || HL / National Heart, Lung, and Blood Institute : NHLBI
- Language
- English
- Date published
- 12/09/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984000923802771
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