Nanoparticle delivery systems in cancer vaccines

Yogita Krishnamachari; Sean M Geary; Caitlin D Lemke; Aliasger K Salem

doi:10.1007/s11095-010-0241-4

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Nanoparticle delivery systems in cancer vaccines

Journal article

Open access

Peer reviewed

Nanoparticle delivery systems in cancer vaccines

Yogita Krishnamachari, Sean M Geary, Caitlin D Lemke and Aliasger K Salem

Pharmaceutical research, Vol.28(2), pp.215-236

02/2011

DOI: 10.1007/s11095-010-0241-4

PMCID: PMC3559243

PMID: 20721603

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Abstract

Therapeutic strategies that involve the manipulation of the host's immune system are gaining momentum in cancer research. Antigen-loaded nanocarriers are capable of being actively taken up by antigen-presenting cells (APCs) and have shown promising potential in cancer immunotherapy by initiating a strong immunostimulatory cascade that results in potent antigen-specific immune responses against the cancer. Such carrier systems offer versatility in that they can simultaneously co-deliver adjuvants with the antigens to enhance APC activation and maturation. Furthermore, modifying the surface properties of these nanocarriers affords active targeting properties to APCs and/or enhanced accumulation in solid tumors. Here, we review some recent advances in these colloidal and particulate nanoscale systems designed for cancer immunotherapy and the potential for these systems to translate into clinical cancer vaccines.

Immunotherapy - methods

Adjuvants, Immunologic - administration & dosage

Nanoparticles - chemistry

Antigens, Neoplasm - immunology

Humans

Antigen-Presenting Cells - immunology

Drug Carriers

Drug Delivery Systems

Cancer Vaccines - immunology

Cancer Vaccines - therapeutic use

Neoplasms - therapy

Animals

Neoplasms - immunology

Nanomedicine - methods

Mice

Details

Title: Subtitle: Nanoparticle delivery systems in cancer vaccines
Creators: Yogita Krishnamachari - Department of Pharmaceutical Sciences & Experimental Therapeutics College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, USA
Sean M Geary
Caitlin D Lemke
Aliasger K Salem
Resource Type: Journal article
Publication Details: Pharmaceutical research, Vol.28(2), pp.215-236
DOI: 10.1007/s11095-010-0241-4
PMID: 20721603
PMCID: PMC3559243
NLM abbreviation: Pharm Res
ISSN: 0724-8741
eISSN: 1573-904X
Publisher: United States
Grant note: 1R21CA13345-01 / NCI NIH HHS R21 CA128414 / NCI NIH HHS 1R21CA128414-01A2/UI / NCI NIH HHS R21 CA133456 / NCI NIH HHS
Language: English
Date published: 02/2011
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering; Holden Comprehensive Cancer Center
Record Identifier: 9983985879302771

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