Journal article
Nanostructured Clays Used as Carriers for Controlled Delivery of Antibacterial Compounds From Direct Restorative Dental Materials: A Scoping Review
Clinical and experimental dental research, Vol.11(5), e70219
10/2025
DOI: 10.1002/cre2.70219
PMCID: PMC12415706
PMID: 40919659
Appears in UI Libraries Support Open Access
Abstract
Objective
Through a scoping review, this study meticulously mapped and characterized these nanostructured clays used to release antibacterial active compounds from direct restorative dental materials.
Material and Methods
The systematic approach involved searches in the PubMed/MEDLINE, Lilacs, Web of Science, Scopus, ScienceDirect, and Embase databases. Two independent and calibrated researchers (kappa: 0.94) performed all systematic steps according to the PRISMA guideline and the Joanna Briggs Institute Scoping Review Methodology Group (JBI) protocol. The reviewers developed a data extraction table to gather key information.
Results
A total of 782 articles were retrieved in the initial search using the specified strategies. After thoroughly reviewing the manuscripts, five were selected following the exclusion of duplicates and application of eligibility criteria. Montmorillonite and halloysite nanotubes emerged as the predominant nanostructured clay. Cetylpyridinium chloride was the most common active agent, notable for its antibacterial properties. Resin-based composites were the most frequently studied direct restorative material for the prevention of recurrent caries.
Conclusion
Although the number of primary studies published in the literature was limited, montmorillonite and halloysite nanotubes appear to be promising nanocarriers for antibacterial active compounds in direct restorative dental materials.
Details
- Title: Subtitle
- Nanostructured Clays Used as Carriers for Controlled Delivery of Antibacterial Compounds From Direct Restorative Dental Materials: A Scoping Review
- Creators
- Bárbara Faria Sa de Barbosa - Universidade Federal do Rio Grande do NorteJosé Leôncio Ferreira Neto - Universidade Federal do Rio Grande do NorteFrancisca Jennifer Duarte de Oliveira - Universidade Federal do Rio Grande do NorteJuliana Sales Osterno Leitão - Universidade Federal do CearáMoan Jéfter Fernandes Costa - Universidade de PernambucoPedro Henrique Sette-de-Souza - Universidade de PernambucoPierre Basílio Almeida Fechine - Universidade Federal do CearáVictor Pinheiro Feitosa - University of IowaBoniek Castillo Dutra Borges - Universidade Federal do Rio Grande do Norte
- Resource Type
- Journal article
- Publication Details
- Clinical and experimental dental research, Vol.11(5), e70219
- DOI
- 10.1002/cre2.70219
- PMID
- 40919659
- PMCID
- PMC12415706
- NLM abbreviation
- Clin Exp Dent Res
- ISSN
- 2057-4347
- eISSN
- 2057-4347
- Publisher
- Wiley
- Language
- English
- Date published
- 10/2025
- Academic Unit
- Operative Dentistry
- Record Identifier
- 9984962645802771
Metrics
5 Record Views