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Nanotechnology in Radiation Oncology
Journal article   Open access   Peer reviewed

Nanotechnology in Radiation Oncology

Bo Sun, C. Tilden Hagan, Joseph Caster and Andrew Z. Wang
Hematology/oncology clinics of North America, Vol.33(6), pp.1071-1093
12/2019
DOI: 10.1016/j.hoc.2019.08.002
PMCID: PMC6981287
PMID: 31668207
url
https://www.ncbi.nlm.nih.gov/pmc/articles/6981287View
Open Access

Abstract

Nanotechnology has made remarkable contributions to clinical oncology. Nanotherapeutics and diagnostic tools have distinctive characteristics which allow them superior abilities to deliver therapeutics and imaging agents for radiation oncology. Compared to solid biopsies and imaging, the analysis of circulating tumor cells (CTCs) offers a more rapid, real-time, and less invasive method to monitor the dynamic molecular profiles of tumors. The potential of CTCs to be translated as a novel cancer biomarker has been demonstrated in numerous clinical studies. This review will discuss clinical applications of nanomaterials in radiation oncology and the implication of CTCs in cancer detection and monitoring.
Cancer biomarkers Circulating tumor cells Circulating tumor DNA Liquid biopsy Nanoparticles Radiosensitization Radiotherapy Tumor imaging

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