Journal article
Nasal mupirocin ointment decreases the incidence of Staphylococcus aureus bacteraemias in haemodialysis patients
Nephrology, dialysis, transplantation, Vol.8(3), pp.235-239
1993
DOI: 10.1093/oxfordjournals.ndt.a092438
PMID: 8385291
Abstract
The incidence of S. aureus bacteraemia in a haemodialysis unit was studied over 2 years (167.75 patient-years of follow-up) during which nasal calcium mupirocin was used to eradicate nasal S. aureus carriage; this incidence was compared to that previously observed in the same unit before the use of nasal mupirocin (185.8 patient-years). Nasal mupirocin led to eradication of nasal S. aureus carriage in 96.3% of surveillance cultures and to a fourfold reduction in the incidence of S. aureus bacteraemia per patient-year, from 0.097 before mupirocin to 0.024 with mupirocin use (P=0.008). Once or thrice weekly maintenance regimens of mupirocin were equally efficacious. The incidence of bacteraemia caused by other microorganisms was not significantly affected. One single mupirocin-resistant isolate was identified in a nasal surveillance culture. Eradication of S. aureus from the nares did not lead to overgrowth by other microorganisms. Chemoprophylaxis with nasal mupirocin in haemodialysis patients is cost-effective.
Details
- Title: Subtitle
- Nasal mupirocin ointment decreases the incidence of Staphylococcus aureus bacteraemias in haemodialysis patients
- Creators
- J. R Boelaert - Unit for Renal and Infectious Diseases, Algemeen Ziekenhuis Sint Jan Brugge, BelgiumH. W Van Landuyt - Department of Microbiology, Algemeen Ziekenhuis Sint Jan Brugge, BelgiumC. A Godard - Institut Pasteur du Brabant Bruxelles, BelgiumR. F Daneels - Unit for Renal and Infectious Diseases, Algemeen Ziekenhuis Sint Jan Brugge, BelgiumM. L Schurgers - Unit for Renal and Infectious Diseases, Algemeen Ziekenhuis Sint Jan Brugge, BelgiumE. G Matthys - Unit for Renal and Infectious Diseases, Algemeen Ziekenhuis Sint Jan Brugge, BelgiumY. A De Baere - Unit for Renal and Infectious Diseases, Algemeen Ziekenhuis Sint Jan Brugge, BelgiumD. W Gheyle - Unit for Renal and Infectious Diseases, Algemeen Ziekenhuis Sint Jan Brugge, BelgiumB. Z Gordts - Department of Microbiology, Algemeen Ziekenhuis Sint Jan Brugge, BelgiumL. A Herwaldt - Division of General Medicine, Clinical Epidemiology and Health Services Research, University of Iowa Hospitals and Clinics Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Nephrology, dialysis, transplantation, Vol.8(3), pp.235-239
- Publisher
- Oxford University Press
- DOI
- 10.1093/oxfordjournals.ndt.a092438
- PMID
- 8385291
- ISSN
- 0931-0509
- eISSN
- 1460-2385
- Language
- English
- Date published
- 1993
- Academic Unit
- Infectious Diseases; Epidemiology; Internal Medicine
- Record Identifier
- 9984094626202771
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