Journal article
National Amoxicillin-Clavulanate Formulation Use Pattern: A Survey
The journal of pediatric pharmacology and therapeutics, Vol.28(3), pp.192-196
2023
DOI: 10.5863/1551-6776-28.3.192
PMCID: PMC10249967
PMID: 37303763
Abstract
Five commercially available amoxicillin-clavulanate (AMC) ratio formulations contribute to ratio selection variability with efficacy and toxicity implications. The objective of this survey was to determine AMC formulation use patterns across the United States.
A multicenter practitioner survey was distributed to multiple listservs (American College of Clinical Pharmacy pediatrics, infectious diseases, ambulatory care, pharmacy administration; American Society of Health-System Pharmacists; Pediatric Pharmacy Association members), and selected pediatric Vizient members in June 2019. Responses were screened for multiples within institutions. Repeated organization responses were identified (n = 37) and excluded if the duplicate matched another response from the same organization exactly (n = 0).
One hundred ninety independent responses were received. Nearly 62% of respondents represented a children's hospital within an acute care hospital; remainder being from stand-alone children's hospitals. Around 55% of respondents indicated prescribers were responsible for choosing the patient-specific formulation for inpatients. Nearly 70% of respondents indicated multiple formulations were available due to clinical need (efficacy, toxicity, measurable volume), whereas over 40% responded that the number of liquid formulations were limited to decrease the potential for error. Variability was demonstrated among institutions using ≥ 2 different formulations for acute otitis media (AOM), sinusitis, lower respiratory tract infection, skin and soft tissue infection, and urinary tract infection (33.6%, 37.3%, 41.5%, 35.8%, and 35.8%, respectively). The 14:1 formulation was the most common, but not exclusive, for AOM, sinusitis, and lower respiratory tract infections with 2.1%, 2.1%, and 2.6% of respondents indicating use of the 2:1 formulation and 10.9%, 15%, and 16.6% of respondents indicating use of the 4:1 formulation.
Significant AMC formulation selection variability exists across the United States.
Details
- Title: Subtitle
- National Amoxicillin-Clavulanate Formulation Use Pattern: A Survey
- Creators
- Gretchen Brummel - Vizient Center for Pharmacy Practice Excellence (GB), Irving, TXChad A Knoderer - Butler University
- Resource Type
- Journal article
- Publication Details
- The journal of pediatric pharmacology and therapeutics, Vol.28(3), pp.192-196
- DOI
- 10.5863/1551-6776-28.3.192
- PMID
- 37303763
- PMCID
- PMC10249967
- NLM abbreviation
- J Pediatr Pharmacol Ther
- ISSN
- 1551-6776
- eISSN
- 2331-348X
- Language
- English
- Date published
- 2023
- Academic Unit
- Pharmacy Practice and Science
- Record Identifier
- 9984771650002771
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