National Cancer Data Base report on malignant paragangliomas of the head and neck

John H Lee; Frank Barich; Lucy Hynds Karnell; Robert A Robinson; Weining K Zhen; Bruce J Gantz; Henry T Hoffman; American College of Surgeons Commission on Cancer and the American Cancer Society

doi:10.1002/cncr.10252

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National Cancer Data Base report on malignant paragangliomas of the head and neck

Journal article

Peer reviewed

National Cancer Data Base report on malignant paragangliomas of the head and neck

John H Lee, Frank Barich, Lucy Hynds Karnell, Robert A Robinson, Weining K Zhen, Bruce J Gantz, Henry T Hoffman and American College of Surgeons Commission on Cancer and the American Cancer Society

Cancer, Vol.94(3), pp.730-737

02/01/2002

DOI: 10.1002/cncr.10252

PMID: 11857306

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Abstract

Malignant paragangliomas of the head and neck are rare, with previous reports limited to nine or fewer patients. The current review included 59 cases extracted from the National Cancer Data Base that were diagnosed between 1985-1996. The primary criterion for inclusion in the current study was verified metastatic spread from a paraganglioma of the head and neck. Patterns of presentation and treatment as well as clinically relevant associations were demonstrated in contingency tables. Relative survival was used for analysis of outcome. The average patient age at presentation was 44 years, and gender distribution was equivalent. Metastases were confined to regional lymph nodes in the majority of cases (68.6%), with carotid body tumors found to have an even higher rate of regional confinement (93.8%). Surgery was the most common treatment (76.3%). The use of adjuvant irradiation for regionally confined disease increased across time, from 27% (1985-1990) to 46% (1991-1996). The 5-year relative survival rate was 59.5% (76.8% for regionally confined carcinoma and 11.8% for distant metastasis). Among patients who were followed until death, those treated with adjuvant irradiation had a longer median survival (45 months) compared with those patients who were treated with surgery alone (12 months). Malignant paraganglioma represents metastatic spread of a tumor type that, when restricted to the site of origin, is considered benign. Metastases from malignant paragangliomas of the head and neck usually are regionally confined. The primary management of a recognized malignancy should be directed toward complete surgical removal of the primary tumor and regional lymph nodes. Postoperative irradiation may be beneficial in slowing the progression of residual disease.

Paraganglioma - pathology

Prognosis

Humans

Middle Aged

Male

Head and Neck Neoplasms - pathology

Neoplasm Metastasis

Paraganglioma - surgery

Head and Neck Neoplasms - epidemiology

Age of Onset

Sex Factors

Survival Analysis

Aged, 80 and over

Adult

Female

Paraganglioma - epidemiology

Aged

Radiotherapy, Adjuvant

Head and Neck Neoplasms - surgery

Databases, Factual

Details

Title: Subtitle: National Cancer Data Base report on malignant paragangliomas of the head and neck
Creators: John H Lee - Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
Frank Barich
Lucy Hynds Karnell
Robert A Robinson
Weining K Zhen
Bruce J Gantz
Henry T Hoffman
American College of Surgeons Commission on Cancer and the American Cancer Society
Resource Type: Journal article
Publication Details: Cancer, Vol.94(3), pp.730-737
DOI: 10.1002/cncr.10252
PMID: 11857306
NLM abbreviation: Cancer
ISSN: 0008-543X
eISSN: 1097-0142
Publisher: United States
Language: English
Date published: 02/01/2002
Academic Unit: Oral Pathology, Radiology and Medicine; Pathology; Radiation Oncology; Neurosurgery; Otolaryngology
Record Identifier: 9984006423402771

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