National Cancer Data Base report on osteosarcoma of the head and neck

Russell B Smith; Louis W Apostolakis; Lucy H Karnell; Brenton B Koch; Robert A Robinson; Weining Zhen; Herman R Menck; Henry T Hoffman

doi:10.1002/cncr.11716

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National Cancer Data Base report on osteosarcoma of the head and neck

Journal article

Open access

Peer reviewed

National Cancer Data Base report on osteosarcoma of the head and neck

Russell B Smith, Louis W Apostolakis, Lucy H Karnell, Brenton B Koch, Robert A Robinson, Weining Zhen, Herman R Menck and Henry T Hoffman

Cancer, Vol.98(8), pp.1670-1680

10/15/2003

DOI: 10.1002/cncr.11716

PMID: 14534884

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Abstract

Osteosarcoma is the most common primary bone malignancy overall but is encountered infrequently in the head and neck. Limited data are available on the significance of prognostics factors and results of therapy for patients with head and neck osteosarcoma (HNOS). It is known that surgical therapy is critical to successful outcome. The impact of adjuvant chemotherapy has not been defined well. The National Cancer Data Base has collected data on cases of HNOS by voluntary accrual from participating hospitals. This database was used to assess patient demographics, tumor characteristics, treatment, and outcome for an 11-year period extending from 1985 to 1996. The data set contained 496 cases of HNOS. Overall, the 5-year disease-specific survival rate was 59.7%. Factors associated with a poor prognosis were age older than 60 years; nonmandibular tumor location; tumor size > 6 cm; histologic type of osteoblastic, not otherwise specified (NOS); advanced disease stage; nonsurgical initial therapy; and positive margins of resection. Increased use of multimodality therapy was noted during the later years of the study. No substantial difference in the 5-year survival rate was noted between treatment with surgery alone (74.7%) and surgery with adjuvant chemotherapy (71.3%), despite the greater prevalence of tumors with poor prognostic factors in the surgery and adjuvant chemotherapy group. Surgery with clear margins is an important factor in successful therapy for patients with HNOS. Improved survival has been noted within the last 2 decades compared with historic controls. Multiple negative prognostic factors have been identified and should be considered in treatment planning. The role of chemotherapy has not been defined well, but its incorporation into treatment of patients with high-risk tumors may improve survival.

Bone Neoplasms - mortality

Osteosarcoma - mortality

Bone Neoplasms - therapy

Humans

Middle Aged

Head and Neck Neoplasms - therapy

Male

Bone Neoplasms - pathology

Head and Neck Neoplasms - pathology

Adult

Female

Aged

Head and Neck Neoplasms - mortality

Neoplasm Staging

Osteosarcoma - therapy

Osteosarcoma - pathology

Details

Title: Subtitle: National Cancer Data Base report on osteosarcoma of the head and neck
Creators: Russell B Smith - Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Louis W Apostolakis
Lucy H Karnell
Brenton B Koch
Robert A Robinson
Weining Zhen
Herman R Menck
Henry T Hoffman
Resource Type: Journal article
Publication Details: Cancer, Vol.98(8), pp.1670-1680
Publisher: United States
DOI: 10.1002/cncr.11716
PMID: 14534884
ISSN: 0008-543X
eISSN: 1097-0142
Language: English
Date published: 10/15/2003
Academic Unit: Oral Pathology, Radiology and Medicine; Pathology; Radiation Oncology; Otolaryngology
Record Identifier: 9984006431802771

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