National surveillance of nosocomial blood stream infection due to Candida albicans: frequency of occurrence and antifungal susceptibility in the SCOPE Program

M A Pfaller; R N Jones; S A Messer; M B Edmond; R P Wenzel

doi:10.1016/S0732-8893(97)00240-X

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National surveillance of nosocomial blood stream infection due to Candida albicans: frequency of occurrence and antifungal susceptibility in the SCOPE Program

Journal article

Peer reviewed

National surveillance of nosocomial blood stream infection due to Candida albicans: frequency of occurrence and antifungal susceptibility in the SCOPE Program

M A Pfaller, R N Jones, S A Messer, M B Edmond and R P Wenzel

Diagnostic microbiology and infectious disease, Vol.31(1), pp.327-332

05/1998

DOI: 10.1016/S0732-8893(97)00240-X

PMID: 9597393

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Abstract

Surveillance of nosocomial blood stream infections (BSI) in the USA between April 1995 and June 1996 revealed that Candida was the fourth leading cause of nosocomial BSI, accounting for 8% of all infections. Fifty-two percent of 379 episodes of candidemia were due to Candida albicans. In vitro susceptibility studies using the 1997 National Committee for Clinical Laboratory Standards reference method demonstrated that 92% of C. albicans isolates were susceptible to 5-fluorocytosine and 90% were susceptible to fluconazole and itraconazole. Geographic variation in susceptibility of fluconazole and itraconazole was observed. Isolates from the Northwest and Southeast regions were more frequently resistant to fluconazole (13.3-15.5%) and to itraconazole (17.2-20.0%) than those from the Northeast and Southwest regions (2.9-5.5% resistant to fluconazole and itraconazole). Continued surveillance for infections caused by C. albicans and other species of Candida among hospitalized patients is recommended.

Antifungal Agents - pharmacology

Fluconazole - pharmacology

Humans

Candidiasis - microbiology

Fungemia - microbiology

Cross Infection - drug therapy

Itraconazole - pharmacology

Microbial Sensitivity Tests

Drug Resistance, Microbial

Candida albicans - drug effects

Candidiasis - drug therapy

Fungemia - drug therapy

Candida albicans - isolation & purification

Cross Infection - microbiology

Details

Title: Subtitle: National surveillance of nosocomial blood stream infection due to Candida albicans: frequency of occurrence and antifungal susceptibility in the SCOPE Program
Creators: M A Pfaller - Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
R N Jones
S A Messer
M B Edmond
R P Wenzel
Resource Type: Journal article
Publication Details: Diagnostic microbiology and infectious disease, Vol.31(1), pp.327-332
Publisher: United States
DOI: 10.1016/S0732-8893(97)00240-X
PMID: 9597393
ISSN: 0732-8893
eISSN: 1879-0070
Language: English
Date published: 05/1998
Academic Unit: Infectious Diseases; Epidemiology; Pathology; Internal Medicine
Record Identifier: 9983905527402771

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