Natural History of Renal Neuroendocrine Neoplasms: A NET by Any Other Name?

Andrew H. Nguyen; Michael P. O’Leary; James P. De Andrade; Philip H. G. Ituarte; Jonathan Kessler; Daneng Li; Gagandeep Singh; Sue Chang

doi:10.3389/fendo.2020.624251

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Natural History of Renal Neuroendocrine Neoplasms: A NET by Any Other Name?

Journal article

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Natural History of Renal Neuroendocrine Neoplasms: A NET by Any Other Name?

Andrew H. Nguyen, Michael P. O’Leary, James P. De Andrade, Philip H. G. Ituarte, Jonathan Kessler, Daneng Li, Gagandeep Singh and Sue Chang

Frontiers in endocrinology (Lausanne), Vol.11, pp.624251-624251

02/05/2021

DOI: 10.3389/fendo.2020.624251

PMCID: PMC7894255

PMID: 33613455

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Abstract

Renal neuroendocrine neoplasms are rare, with descriptions of cases limited to individual reports and small series. The natural history of this group of neuroendocrine neoplasms is poorly understood. In this study, we queried the Surveillance, Epidemiology and End Results (SEER) database over a four-decade period where we identified 166 cases of primary renal neuroendocrine neoplasms. We observed a 5-year overall survival of 50%. On multivariate analysis, survival was influenced by stage, histology, and if surgery was performed. We observed that patients managed by operative management had a greater frequency of localized or regional stage disease as well as a greater frequency of neuroendocrine tumor, grade 1 histology; whereas those managed non-operatively tended to have distant disease and histologies of neuroendocrine carcinoma, NOS and small cell neuroendocrine carcinoma. This is the largest description of patients with renal neuroendocrine neoplasms. Increased survival was observed in patients with earlier stage and favorable histologies.

Endocrinology

kidney

neuroendocrine carcinoma

neuroendocrine neoplasm

neuroendocrine tumor

renal

Details

Title: Subtitle: Natural History of Renal Neuroendocrine Neoplasms: A NET by Any Other Name?
Creators: Andrew H. Nguyen - City Of Hope National Medical Center
Michael P. O’Leary - , , , , , , , , , ,
James P. De Andrade - University of Iowa
Philip H. G. Ituarte - City Of Hope National Medical Center
Jonathan Kessler - City Of Hope National Medical Center
Daneng Li - City Of Hope National Medical Center
Gagandeep Singh - City Of Hope National Medical Center
Sue Chang - City Of Hope National Medical Center
Resource Type: Journal article
Publication Details: Frontiers in endocrinology (Lausanne), Vol.11, pp.624251-624251
DOI: 10.3389/fendo.2020.624251
PMID: 33613455
PMCID: PMC7894255
NLM abbreviation: Front Endocrinol (Lausanne)
ISSN: 1664-2392
eISSN: 1664-2392
Publisher: Frontiers Media S.A
Language: English
Date published: 02/05/2021
Academic Unit: Surgery
Record Identifier: 9984322937702771

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