Natural Killer Cell Recruitment to the Lung During Influenza A Virus Infection Is Dependent on CXCR3, CCR5, and Virus Exposure Dose

Lindsey E Carlin; Emily A Hemann; Zeb R Zacharias; Jonathan W Heusel; Kevin L Legge

doi:10.3389/fimmu.2018.00781

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Natural Killer Cell Recruitment to the Lung During Influenza A Virus Infection Is Dependent on CXCR3, CCR5, and Virus Exposure Dose

Journal article

Open access

Peer reviewed

Natural Killer Cell Recruitment to the Lung During Influenza A Virus Infection Is Dependent on CXCR3, CCR5, and Virus Exposure Dose

Lindsey E Carlin, Emily A Hemann, Zeb R Zacharias, Jonathan W Heusel and Kevin L Legge

Frontiers in immunology, Vol.9, pp.781-781

2018

DOI: 10.3389/fimmu.2018.00781

PMCID: PMC5913326

PMID: 29719539

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Abstract

Natural killer (NK) cells are vital components of the antiviral immune response, but their contributions in defense against influenza A virus (IAV) are not well understood. To better understand NK cell responses during IAV infections, we examined the magnitude, kinetics, and contribution of NK cells to immunity and protection during high- and low-dose IAV infections. Herein, we demonstrate an increased accumulation of NK cells in the lung in high-dose vs. low-dose infections. In part, this increase is due to the local proliferation of pulmonary NK cells. However, the majority of NK cell accumulation within the lungs and airways during an IAV infection is due to recruitment that is partially dependent upon CXCR3 and CCR5, respectively. Therefore, altogether, our results demonstrate that NK cells are actively recruited to the lungs and airways during IAV infection and that the magnitude of the recruitment may relate to the inflammatory environment found within the tissues during high- and low-dose IAV infections.

Mice, Inbred C57BL

Receptors, CCR5 - immunology

Lung - virology

Animals

Influenza A virus

Receptors, CXCR3 - immunology

Killer Cells, Natural - immunology

Mice

Mice, Inbred BALB C

Chemotaxis, Leukocyte - immunology

Orthomyxoviridae Infections - virology

Lung - immunology

Orthomyxoviridae Infections - immunology

Details

Title: Subtitle: Natural Killer Cell Recruitment to the Lung During Influenza A Virus Infection Is Dependent on CXCR3, CCR5, and Virus Exposure Dose
Creators: Lindsey E Carlin - Interdisciplinary Graduate Program in Immunology, Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, United States
Emily A Hemann - Interdisciplinary Graduate Program in Immunology, Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, United States
Zeb R Zacharias - Interdisciplinary Graduate Program in Immunology, Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, United States
Jonathan W Heusel - Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, United States
Kevin L Legge - Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, IA, United States
Resource Type: Journal article
Publication Details: Frontiers in immunology, Vol.9, pp.781-781
DOI: 10.3389/fimmu.2018.00781
PMID: 29719539
PMCID: PMC5913326
NLM abbreviation: Front Immunol
ISSN: 1664-3224
eISSN: 1664-3224
Publisher: Switzerland
Grant note: R01 AI071085 / NIAID NIH HHS R56 AI071085 / NIAID NIH HHS R21 AI076989 / NIAID NIH HHS T32 AI007485 / NIAID NIH HHS
Language: English
Date published: 2018
Academic Unit: Microbiology and Immunology; Pathology
Record Identifier: 9984046934202771

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