Journal article
Natural Tregs, CD4+CD25+ inhibitory hybridomas, and their cell contact dependent suppression
Immunologic research, Vol.39(1), pp.62-78
11/2007
DOI: 10.1007/s12026-007-0064-5
PMID: 17917056
Abstract
The natural CD4+CD25+ T regulatory (Treg) lymphocyte has emerged as a critical cell for controlling immune responses to self, foreign proteins, and pathogens. Identified initially by the constitutive expression of CD4 and CD25, natural Tregs suppress a variety of immune cells and responses, including CD4+CD25− proliferation and IL-2 production, and CD8 cell proliferation, IFNγ production and CTL activity. Although natural Tregs require activation with specific antigen to attain their suppressive phenotype, once activated they execute inhibition in an antigen specific as well as non-specific (bystander) fashion. Treg suppression depends on IL-2, CD25, and cell:cell contact. The use of live cell imaging in vivo and in vitro to visualize the dynamic cell:cell interactions involving natural Tregs as well as the CD4+CD25+ Treg inhibitory hybridoma RD6 has refined the mechanistic models of contact dependent Treg suppression.
Details
- Title: Subtitle
- Natural Tregs, CD4+CD25+ inhibitory hybridomas, and their cell contact dependent suppression
- Creators
- Elizabeth Field - Department of Veterans Affairs Medical Center 10E01 Building 1, Hwy 6 West Iowa City IA 52242-2208 USAKatarina Kulhankova - Department of Veterans Affairs Medical Center 10E01 Building 1, Hwy 6 West Iowa City IA 52242-2208 USAMohamed Nasr - Department of Veterans Affairs Medical Center 10E01 Building 1, Hwy 6 West Iowa City IA 52242-2208 USA
- Resource Type
- Journal article
- Publication Details
- Immunologic research, Vol.39(1), pp.62-78
- Publisher
- Humana Press Inc
- DOI
- 10.1007/s12026-007-0064-5
- PMID
- 17917056
- ISSN
- 0257-277X
- eISSN
- 1559-0755
- Language
- English
- Date published
- 11/2007
- Academic Unit
- Stead Family Department of Pediatrics; Immunology; Internal Medicine
- Record Identifier
- 9984094663502771
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