Journal article
Natural bladder filling alters resting brain function at multiple spatial scales: a proof-of-concept MAPP Network Neuroimaging Study
Scientific reports, Vol.10(1), pp.19901-19901
11/16/2020
DOI: 10.1038/s41598-020-76857-x
PMCID: PMC7669903
PMID: 33199816
Abstract
Neural circuitry regulating urine storage in humans has been largely inferred from fMRI during urodynamic studies driven by catheter infusion of fluid into the bladder. However, urodynamic testing may be confounded by artificially filling the bladder repeatedly at a high rate and examining associated time-locked changes in fMRI signals. Here we describe and test a more ecologically-valid paradigm to study the brain response to bladder filling by (1) filling the bladder naturally with oral water ingestion, (2) examining resting state fMRI (rs-fMRI) which is more natural since it is not linked with a specific stimulus, and (3) relating rs-fMRI measures to self-report (urinary urge) and physiologic measures (voided volume). To establish appropriate controls and analyses for future clinical studies, here we analyze data collected from healthy individuals (N = 62) as part of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Participants orally ingested approximately 350 mL of water, and had a 10 min "fuller bladder" rs-fMRI scan approximately 1 h later. A second 10 min "empty bladder" rs-fMRI scan was conducted immediately following micturition. We examined multiple spatial scales of brain function, including local activity, circuits, and networks. We found changes in brain function distributed across micturition loci (e.g., subregions of the salience, sensorimotor, and default networks) that were significantly related to the stimulus (volume) and response (urinary urge). Based on our results, this paradigm can be applied in the future to study the neurobiological underpinnings of urologic conditions.
Details
- Title: Subtitle
- Natural bladder filling alters resting brain function at multiple spatial scales: a proof-of-concept MAPP Network Neuroimaging Study
- Creators
- Ishtiaq Mawla - Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, USAAndrew Schrepf - Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, USAEric Ichesco - Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, USASteven E Harte - Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, USADavid J Klumpp - Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USAJames W Griffith - Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USAEric Strachan - Department of Psychiatry, University of Washington, Seattle, WA, USAClaire C Yang - Department of Urology, University of Washington, Seattle, WA, USAHenry Lai - Division of Urologic Surgery, Department of Surgery, Washington University, St. Louis, MO, USAGerald Andriole - Division of Urologic Surgery, Department of Surgery, Washington University, St. Louis, MO, USAVincent A Magnotta - Department of Radiology, University of Iowa, Iowa City, IA, USAKarl Kreder - Department of Urology, University of Iowa, Iowa City, IA, USADaniel J Clauw - Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, USARichard E Harris - Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, USAJ Quentin Clemens - Department of Urology, University of Michigan, Ann Arbor, MI, USAJ Richard Landis - Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USAChris Mullins - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USALarissa V Rodriguez - Department of Urology, University of Southern California, Los Angeles, CA, USAEmeran A Mayer - G. Oppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California, Los Angeles, CA, USAJason J Kutch - Division of Biokinesiology and Physical Therapy, University of Southern California, 1540 E. Alcazar Street, CHP 155, Los Angeles, CA, 90033, USA. kutch@usc.edu
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.10(1), pp.19901-19901
- DOI
- 10.1038/s41598-020-76857-x
- PMID
- 33199816
- PMCID
- PMC7669903
- NLM abbreviation
- Sci Rep
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Publisher
- England
- Grant note
- U01 DK082344 / NIDDK NIH HHS DK082316 / NIDDK NIH HHS DK082325 / NIDDK NIH HHS DK082370 / NIDDK NIH HHS R01 DK110669 / NIDDK NIH HHS DK082345 / NIDDK NIH HHS R01 DK121724 / NIDDK NIH HHS DK082342 / NIDDK NIH HHS DK082315 / NIDDK NIH HHS U01 DK082370 / NIDDK NIH HHS DK082344 / NIDDK NIH HHS
- Language
- English
- Date published
- 11/16/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984066392402771
Metrics
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