Journal article
Natural history of pelvic organ prolapse in postmenopausal women
Obstetrics and gynecology, Vol.109(4), pp.848-854
04/2007
DOI: 10.1097/01.AOG.0000255977.91296.5d,
PMID: 17400845
Abstract
To describe the natural history of pelvic organ prolapse and risk factors for changes in vaginal descent in older women. This 4-year prospective observational study included 259 postmenopausal women with a uterus enrolled at one Women's Health Initiative clinical site who completed at least two annual pelvic organ prolapse quantification (POP-Q) examinations. We calculated 1-year and 3-year incidence and resolution risks for prolapse (defined as maximal vaginal descent to or beyond the hymen) and estimated progression and regression rates (1 cm or greater and 2 cm or greater changes in maximal vaginal descent) and risk factors. Mean age was 68.1+/-5.5 years, and median vaginal parity was 4. Seventy-three (28%) women had four exams, 128 (49%) had three exams, and 58 (22%) had two exams. Prolapse waxed and waned yearly in individual women. Overall 1-year and 3-year prolapse incidences were 26% (95% confidence interval [CI] 20-33%) and 40% (95% CI 26-56%); 1-year and 3-year prolapse resolution risks were 21% (95% CI 11-33%) and 19% (95% CI 7-39%). Rates of any change in maximal vaginal descent over time varied depending on baseline measurements. Over 3 years, the maximal vaginal descent increased by at least 2 cm in 11.0% (95% CI 4.9-20.5%) of the women and decreased by at least 2 cm in 2.7% (95% CI 0.3-9.5%). Increasing body mass index and grand multiparity increased the risk for vaginal descent progression. Prolapse progresses and regresses in older women, although rates of vaginal descent progression are slightly greater than regression overall. Obesity is a risk factor for progression in vaginal descent. III.
Details
- Title: Subtitle
- Natural history of pelvic organ prolapse in postmenopausal women
- Creators
- Catherine S Bradley - University of Iowa, EpidemiologyM Bridget Zimmerman - University of Iowa, BiostatisticsYingwei QiIngrid E Nygaard
- Resource Type
- Journal article
- Publication Details
- Obstetrics and gynecology, Vol.109(4), pp.848-854
- Publisher
- United States
- DOI
- 10.1097/01.AOG.0000255977.91296.5d,
- PMID
- 17400845
- ISSN
- 0029-7844
- eISSN
- 1873-233X
- Grant note
- R01 HD4 1131 / NICHD NIH HHS K23 HD047654 / NICHD NIH HHS K24 HD42469 / NICHD NIH HHS
- Language
- English
- Date published
- 04/2007
- Academic Unit
- Epidemiology; Biostatistics; Obstetrics and Gynecology; Urology
- Record Identifier
- 9983557241602771
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