Naturally occurring perinatal growth restriction in mice programs cardiovascular and endocrine function in a sex- and strain-dependent manner

Robert D Roghair; Gilbert Aldape

doi:10.1203/PDR.0b013e31813cbf16

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Naturally occurring perinatal growth restriction in mice programs cardiovascular and endocrine function in a sex- and strain-dependent manner

Journal article

Open access

Peer reviewed

Naturally occurring perinatal growth restriction in mice programs cardiovascular and endocrine function in a sex- and strain-dependent manner

Robert D Roghair and Gilbert Aldape

Pediatric research, Vol.62(4), pp.399-404

10/2007

DOI: 10.1203/PDR.0b013e31813cbf16

PMID: 17667847

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Abstract

Perinatal growth restriction (PGR) is associated with type 2 diabetes and hypertension. Identification of an isogenic mouse model of fetal programming will facilitate mechanistic understanding. We sought to test the hypotheses that 1) PGR impairs glucose tolerance and induces hypertension; and 2) the programming phenotype is more severe in an inbred mouse strain susceptible to diabetes (C57BL/6) than in a strain without such genetic predisposition (DBA/2). PGR pups were paired at weaning with same sex normally grown littermates. Glucose and insulin tolerance tests were performed at 17 wk, and systolic blood pressure (SBP) was measured at 20 wk. Impaired glucose tolerance was evident only among female PGR mice from both strains. While PGR did not alter insulin sensitivity in either strain, female DBA/2 mice had significantly decreased insulin levels during glucose tolerance testing. SBP was increased in PGR male C57BL/6 mice (p<0.01), while heart rate was decreased in PGR male DBA/2 mice (p<0.05). These studies indicate that in isogenic mice, PGR alters endocrine and cardiovascular physiology in female and male mice, respectively. Strain-and sex-specific genetic susceptibilities emphasize the need to consider genetic predisposition when evaluating the role of the perinatal environmental in the inception of adult disease.

Blood Pressure

Glucose Intolerance - metabolism

Body Weight

Species Specificity

Diabetes Mellitus, Type 2 - genetics

Endocrine System - physiopathology

Male

Diabetes Mellitus, Type 2 - metabolism

Endocrine System - embryology

Cardiovascular System - physiopathology

Endocrine System - metabolism

Diabetes Mellitus, Type 2 - embryology

Female

Mice, Inbred DBA

Cardiovascular System - embryology

Glucose Intolerance - physiopathology

Severity of Illness Index

Heart Rate

Genetic Predisposition to Disease

Glucose Intolerance - genetics

Glucose Tolerance Test

Mice, Inbred C57BL

Insulin Resistance

Fetal Growth Retardation - metabolism

Hypertension - physiopathology

Fetal Growth Retardation - physiopathology

Glucose Intolerance - embryology

Insulin - metabolism

Phenotype

Animals

Diabetes Mellitus, Type 2 - physiopathology

Hypertension - embryology

Sex Factors

Mice

Blood Glucose - metabolism

Details

Title: Subtitle: Naturally occurring perinatal growth restriction in mice programs cardiovascular and endocrine function in a sex- and strain-dependent manner
Creators: Robert D Roghair - Department of Pediatrics, University of Iowa, Iowa, IA 52242, USA. robert-roghair@uiowa.edu
Gilbert Aldape
Resource Type: Journal article
Publication Details: Pediatric research, Vol.62(4), pp.399-404
DOI: 10.1203/PDR.0b013e31813cbf16
PMID: 17667847
ISSN: 0031-3998
eISSN: 1530-0447
Grant note: K08HD050359 / NICHD NIH HHS
Language: English
Date published: 10/2007
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984093353602771

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18 Times Cited - Web of Science