Journal article
Naturally occurring ureidobromophenols with potent antioxidant activities from the marine red alga Rhodomela confervoides
Algal research (Amsterdam), Vol.56, p.102312
06/2021
DOI: 10.1016/j.algal.2021.102312
Abstract
An extensive investigation on the chemical components with potential antioxidant activity resulted in the characterization of four new ureidobromophenols (1–4) and two related metabolites (5 and 6) from ethyl acetate extract of the marine red alga Rhodomela confervoides. Their structures were determined using spectroscopic analysis and comparisons with known compounds. Compound 1 possesses unique structure of an ureido group bearing γ-butyric acid and 2,3-dibromo-4,5-dihydroxybenzyl moieties on the same nitrogen atom. Compounds 1–4 displayed significant antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals with IC50 values ranging from 3.34 to 4.84 μM, which are more active than that of the positive controls ascorbic acid (IC50 = 20.1 μM) and butylated hydroxytoluene (IC50 = 82.1 μM). These compounds also exhibited potent activity against 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonate (ABTS) radicals with trolox equivalent antioxidant capacity (TEAC) values ranging from 3.25 to 5.01 mM, which are 3- to 5-fold potent than that of ascorbic acid (TEAC = 1.02 mM). The antioxidant activity of ureidobromophenols isolated from marine alga might boost the seaweed functional food ingredients or dietary food supplements in food industry.
•Four new ureidobromophenols were identified from marine red alga Rhodomela confervoides.•Compound 1 features bromophenol and butyric acid units coupled to the same N-atom of an ureido moiety.•Other isolated ureidobromophenols possess potent activity against DPPH and ABTS radicals.
Details
- Title: Subtitle
- Naturally occurring ureidobromophenols with potent antioxidant activities from the marine red alga Rhodomela confervoides
- Creators
- Ke Li - CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Nanhai Road 7, Qingdao 266071, People's Republic of ChinaXiao-Ming Li - CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Nanhai Road 7, Qingdao 266071, People's Republic of ChinaJames B Gloer - Department of Chemistry, University of Iowa, Iowa City, IA 52242, United StatesBin-Gui Wang - CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Nanhai Road 7, Qingdao 266071, People's Republic of China
- Resource Type
- Journal article
- Publication Details
- Algal research (Amsterdam), Vol.56, p.102312
- DOI
- 10.1016/j.algal.2021.102312
- ISSN
- 2211-9264
- eISSN
- 2211-9264
- Publisher
- Elsevier B.V
- Grant note
- DOI: 10.13039/501100001809, name: National Natural Science Foundation of China
- Language
- English
- Date published
- 06/2021
- Academic Unit
- Chemistry
- Record Identifier
- 9984217556702771
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